bpV(phen) (potassium hydrate)

• CAT Number: R064423
• CAS Number: 171202-16-7
• Molecular Formula: C12H8N2O5V • K+(H2O)3
• Molecular Weight: 404.3
• Purity: ≥95%
• Storage: -20°C
• InChI: InChI=1S/C12H8N2.K.2O2.3H2O.O.V/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1;;2*1-2;;;;;/h1-8H;;;;3*1H2;;/q;+1;2*-2;;;;;+3
• InChIKey: TYPQOCBUPQJDHB-UHFFFAOYSA-N
• SMILES: O=[V+3]123([O-][O-]2)([O-][O-]3)[N]4=C(C([N]1=CC=C5)=C5C=C6)C6=CC=C4.O.O.O.[K+]

bpV(phen) is a bisperoxovanadium (bpV) compound which inhibits several different protein tyrosine phosphatases (PTPs), with selectivity for PTEN (IC50 = 38 nM). It also inhibits the vascular endothelial PTP, PTP-<wbr></wbr>β (IC50 = 343 nM), and PTP-<wbr></wbr>1β (IC50 = 920 nM). At 0.1 mM, bpV(phen) inhibits SH2 domain-<wbr></wbr>containing inositol 5’-<wbr></wbr>phosphatase-<wbr></wbr>2. Presumably by inhibiting insulin receptor kinase-<wbr></wbr>associated PTPs, bpV(phen) activates the insulin receptor tyrosine kinase and promotes downstream signaling, including activation of PI3-<wbr></wbr>kinase.

Reference

1.Lai, J.P.,Dalton, J.T., and Knoell, D.L. Phosphatase and tensin homologue deleted on chromosome ten (PTEN) as a molecular target in lung epithelial wound repair. British Journal of Pharmacology 152(8), 1172-1184 (2007).