For research use only. Not for therapeutic Use.
BPK-21（Cat No.:I045265）is a potent and selective inhibitor of cyclin-dependent kinase 9 (CDK9), an essential enzyme that controls transcriptional elongation by phosphorylating the RNA polymerase II C-terminal domain. Inhibiting CDK9 with BPK-21 reduces transcription of short-lived anti-apoptotic and oncogenic proteins such as MCL-1 and MYC, triggering apoptosis in cancer cells reliant on continuous transcription. This compound has demonstrated strong activity in preclinical cancer models, particularly in hematologic malignancies. With high selectivity, cellular potency, and suitability for mechanistic studies, BPK-21 is a valuable tool for investigating transcriptional regulation and CDK9-targeted therapeutic strategies.
| CAS Number | 2305052-77-9 |
| Synonyms | N-[(2,3-dichlorophenyl)methyl]-N-[4-phenoxy-3-(trifluoromethyl)phenyl]prop-2-enamide |
| Molecular Formula | C23H16Cl2F3NO2 |
| Purity | ≥95% |
| IUPAC Name | N-[(2,3-dichlorophenyl)methyl]-N-[4-phenoxy-3-(trifluoromethyl)phenyl]prop-2-enamide |
| InChI | InChI=1S/C23H16Cl2F3NO2/c1-2-21(30)29(14-15-7-6-10-19(24)22(15)25)16-11-12-20(18(13-16)23(26,27)28)31-17-8-4-3-5-9-17/h2-13H,1,14H2 |
| InChIKey | LTDXUNCJQPHZOF-UHFFFAOYSA-N |
| SMILES | C=CC(=O)N(CC1=C(C(=CC=C1)Cl)Cl)C2=CC(=C(C=C2)OC3=CC=CC=C3)C(F)(F)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
