For research use only. Not for therapeutic Use.
BMS-820132（Cat No.:I044056）is a selective and potent inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4), a key mediator in Toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) signaling pathways. By blocking IRAK4 activity, BMS-820132 suppresses downstream activation of NF-κB and MAPK pathways, reducing the production of pro-inflammatory cytokines. This compound is particularly valuable in research focused on autoimmune and inflammatory diseases, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis. BMS-820132 supports therapeutic exploration of innate immune signaling modulation and offers a promising approach for controlling chronic inflammation and immune dysregulation.
| CAS Number | 1001419-18-6 |
| Synonyms | 3-[5-(azetidine-1-carbonyl)pyrazin-2-yl]oxy-N-[1-(diethoxyphosphorylmethyl)pyrazol-3-yl]-5-propan-2-yloxybenzamide |
| Molecular Formula | C26H33N6O7P |
| Purity | ≥95% |
| IUPAC Name | 3-[5-(azetidine-1-carbonyl)pyrazin-2-yl]oxy-N-[1-(diethoxyphosphorylmethyl)pyrazol-3-yl]-5-propan-2-yloxybenzamide |
| InChI | InChI=1S/C26H33N6O7P/c1-5-36-40(35,37-6-2)17-32-11-8-23(30-32)29-25(33)19-12-20(38-18(3)4)14-21(13-19)39-24-16-27-22(15-28-24)26(34)31-9-7-10-31/h8,11-16,18H,5-7,9-10,17H2,1-4H3,(H,29,30,33) |
| InChIKey | OYUDYQMFVRHPIY-UHFFFAOYSA-N |
| SMILES | CCOP(=O)(CN1C=CC(=N1)NC(=O)C2=CC(=CC(=C2)OC(C)C)OC3=NC=C(N=C3)C(=O)N4CCC4)OCC |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
