BMS-5

• CAT Number: I001289
• CAS Number: 1338247-35-0
• Molecular Formula: C17H14Cl2F2N4OS
• Molecular Weight: 431.3
• Purity: ≥95%
• Target: LIM kinase inhibitor
• Solubility: DMSO: ＞ 34 mg/mL
• Storage: -20°C
• IUPAC Name: N-[5-[2-(2,6-dichlorophenyl)-5-(difluoromethyl)pyrazol-3-yl]-1,3-thiazol-2-yl]-2-methylpropanamide
• InChI: InChI=1S/C17H14Cl2F2N4OS/c1-8(2)16(26)23-17-22-7-13(27-17)12-6-11(15(20)21)24-25(12)14-9(18)4-3-5-10(14)19/h3-8,15H,1-2H3,(H,22,23,26)
• InChIKey: IVUGBSGLHRJSSP-UHFFFAOYSA-N
• SMILES: CC(C)C(=O)NC1=NC=C(S1)C2=CC(=NN2C3=C(C=CC=C3Cl)Cl)C(F)F

BMS-5（Cat No.:I001289） is a potent inhibitor of LIM kinase, with IC50 values of 7 nM for LIMK1 and 8 nM for LIMK2. LIM kinases are enzymes involved in the regulation of actin cytoskeleton dynamics and cell motility. By specifically targeting LIMK1 and LIMK2, BMS-5 inhibits their activity and disrupts actin filament organization. This inhibition may have potential applications in the treatment of diseases related to abnormal cell motility, such as cancer metastasis or neurodegenerative disorders.

Reference

[1]. Sparrow N1, Manetti ME et al。The Actin-Severing Protein Cofilin Is Downstream of Neuregulin Signaling and Is Essential For Schwann Cell Myelination. J Neurosci. 2012 Apr 11; 32(15): 5284–5297.

[2]. Alejandra Petrilli, Alicja Copik et al。LIM Domain Kinases as Potential Therapeutic Targets for Neurofibromatosis Type 2.Oncogene. 2014 Jul 3; 33(27): 3571–3582..

[3]. Weiwei Wang and Ellen Townes-Andersonl。LIM Kinase, a Newly Identified Regulator of Presynaptic Remodeling by Rod Photoreceptors After Injury.Invest Ophthalmol Vis Sci. 2015 Dec; 56(13): 7847–7858.