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BMS-191095

BMS-191095

  • CAT Number: I002173
  • CAS Number: 166095-21-2
  • Molecular Formula: C22H21ClN4O2
  • Molecular Weight: 408.88
  • Purity: ≥95%
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<p style=/line-height:25px/>BMS-191095 is an activators of mitochondrial ATP-sensitive potassium (mitoKATP) channels.<br>Target: potassium channel<br>in vitro: BMS-191095 induces mitochondrial-depolarization and vasodilation. BMS-191095 elicites a dose-dependent vasodilation in endothelium denuded cerebral arteries with 8.1 ± 2.3%, 31.6 ± 2.1%, and 39.5 ± 3.2% relaxation in response to 10, 50, and 100 μM, respectively.<br>in vivo: In normal rats, BMS-191095-induced vasodilation was mediated by mitochondrial depolarization and calcium sparks generation in VSM and was reduced by inhibition of BKCa channels.</p>

Catalog Number I002173
CAS Number 166095-21-2
Molecular Formula

C22H21ClN4O2

Purity 95%
Target potassium channel
Solubility DMSO: ≥ 50 mg/mL
Storage -20°C
Reference

<p style=/line-height:25px/>
<br>[1]. Katakam PV, et al. Diversity of mitochondria-dependent dilator mechanisms in vascular smooth muscle of cerebral arteries from normal and insulin-resistant rats. Am J Physiol Heart Circ Physiol. 2014 Aug 15;307(4):H493-503.
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