BMPO

• CAT Number: R064940
• CAS Number: 387334-31-8
• Molecular Formula: C10H17NO3
• Molecular Weight: 199.2
• Purity: ≥95%
• Synonyms: BocMPO
• Storage: -20°C
• InChI: InChI=1S/C10H17NO3/c1-9(2,3)14-8(12)10(4)6-5-7-11(10)13/h7H,5-6H2,1-4H3
• InChIKey: MDMUYJRRYYXDLZ-UHFFFAOYSA-N
• SMILES: [O-][N+]1=CCCC1(C)C(OC(C)(C)C)=O

BMPO is a cyclic nitrone spin trap that can be used for the detection and characterization of thiyl radicals, hydroxyl radicals, and superoxide anions in vitro or in vivo. The BMPO-<wbr></wbr>superoxide adduct does not rapidly decompose to the hydroxyl adduct in cells (t½ = 23 min). Also, the ESR spectrum of the BMPO-<wbr></wbr>glutathionyl adduct does not fully overlap with the spectrum of its hydroxyl adduct. Purified by crystallization and stored as a solid, BMPO has a longer shelf life than liquid spin traps.

Reference

1.Zhao, H.,Joseph, J.,Zhang, H., et al. Synthesis and biochemical applications of a solid cyclic nitrone spin trap: A relatively superior trap for detecting superoxide anions and glutathiyl radicals. Free Radical Biology & Medicine 31(5), 599-606 (2001).