For research use only. Not for therapeutic Use.
BLU-945（Cat No.:I044044）is a next-generation, highly selective inhibitor of mutant epidermal growth factor receptor (EGFR) variants, specifically designed to target resistant EGFR mutations such as T790M and C797S found in non-small cell lung cancer (NSCLC). By sparing wild-type EGFR, BLU-945 minimizes off-target toxicity while effectively suppressing oncogenic signaling in treatment-resistant tumors. It is particularly valuable in overcoming resistance to first- and third-generation EGFR tyrosine kinase inhibitors. BLU-945 supports research into precision oncology and combination therapies aimed at durable responses in EGFR-mutant NSCLC and other EGFR-driven malignancies.
| CAS Number | 2660250-10-0 |
| Synonyms | N-[2-[(3S,4R)-3-fluoro-4-methoxypiperidin-1-yl]pyrimidin-4-yl]-8-[(2R,3S)-2-methyl-3-(methylsulfonylmethyl)azetidin-1-yl]-5-propan-2-ylisoquinolin-3-amine |
| Molecular Formula | C28H37FN6O3S |
| Purity | ≥95% |
| IUPAC Name | N-[2-[(3S,4R)-3-fluoro-4-methoxypiperidin-1-yl]pyrimidin-4-yl]-8-[(2R,3S)-2-methyl-3-(methylsulfonylmethyl)azetidin-1-yl]-5-propan-2-ylisoquinolin-3-amine |
| InChI | InChI=1S/C28H37FN6O3S/c1-17(2)20-6-7-24(35-14-19(18(35)3)16-39(5,36)37)22-13-31-27(12-21(20)22)32-26-8-10-30-28(33-26)34-11-9-25(38-4)23(29)15-34/h6-8,10,12-13,17-19,23,25H,9,11,14-16H2,1-5H3,(H,30,31,32,33)/t18-,19-,23+,25-/m1/s1 |
| InChIKey | LIMFPAAAIVQRRD-BCGVJQADSA-N |
| SMILES | C[C@@H]1[C@H](CN1C2=C3C=NC(=CC3=C(C=C2)C(C)C)NC4=NC(=NC=C4)N5CC[C@H]([C@H](C5)F)OC)CS(=O)(=O)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
