For research use only. Not for therapeutic Use.
BIZ 114 (CAT: I016829) is a fatty acid derivative that potently inhibits the TNF-α–activated NF-κB signaling pathway, a central regulator of inflammation and cell survival. By targeting this pathway, BIZ 114 shows strong potential for the prevention and treatment of ophthalmic disorders, particularly retinal degenerative diseases such as age-related macular degeneration (AMD) and diabetic retinopathy, as well as ocular inflammatory conditions. As a polyunsaturated fatty acid–based compound, it also influences lipid metabolism, membrane composition, and gene expression. BIZ 114 serves as a promising therapeutic lead and research tool in inflammation, ophthalmology, and retinal disease biology.
| CAS Number | 2099120-74-6 |
| Synonyms | 2-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoxy]butanoic acid |
| Molecular Formula | C24H40O3 |
| Purity | ≥95% |
| IUPAC Name | 2-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoxy]butanoic acid |
| InChI | InChI=1S/C24H40O3/c1-3-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27-23(4-2)24(25)26/h8-9,11-12,14-15,17-18,23H,3-7,10,13,16,19-22H2,1-2H3,(H,25,26)/b9-8-,12-11-,15-14-,18-17- |
| InChIKey | JJBSGIKIKLMNBG-GKFVBPDJSA-N |
| SMILES | CCCCCC=CCC=CCC=CCC=CCCCCOC(CC)C(=O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
