Bithionol

• CAT Number: I005709
• CAS Number: 97-18-7
• Molecular Formula: C12H6Cl4O2S
• Molecular Weight: 356.1
• Purity: ≥95%
• Target: Adenylate cyclase
• Solubility: DMSO: ≥ 33 mg/mL
• Storage: Store at -20°C
• InChI: InChI=1S/C12H6Cl4O2S/c13-5-1-7(15)11(17)9(3-5)19-10-4-6(14)2-8(16)12(10)18/h1-4,17-18H
• InChIKey: JFIOVJDNOJYLKP-UHFFFAOYSA-N
• SMILES: ClC1=CC(Cl)=CC(SC2=CC(Cl)=CC(Cl)=C2O)=C1O

Bithionol(CAT: I005709), a clinically approved anti-parasitic drug, exhibits a multifaceted pharmacological profile. Beyond its established anti-parasitic action, Bithionol demonstrates promise as an anticancer agent. In preclinical cancer models, it has shown the ability to inhibit solid tumor growth. The underlying mechanisms behind its anti-tumor effects are complex and may involve modulation of various cellular pathways. The dual functionality of Bithionol in targeting both parasitic infections and potentially inhibiting tumor growth underscores its potential utility in diverse therapeutic contexts, making it an intriguing candidate for further investigation and potential repurposing for cancer treatment.

Reference

1:Evaluation of the cytotoxicity of the Bithionol – cisplatin combination in a panel of human ovarian cancer cell lines. Ayyagari VN, Hsieh TJ, Diaz-Sylvester PL, Brard L.BMC Cancer. 2017 Jan 13;17(1):49. doi: 10.1186/s12885-016-3034-2. PMID: 28086831 Free PMC Article2:Bithionol blocks pathogenicity of bacterial toxins, ricin, and Zika virus. Leonardi W, Zilbermintz L, Cheng LW, Zozaya J, Tran SH, Elliott JH, Polukhina K, Manasherob R, Li A, Chi X, Gharaibeh D, Kenny T, Zamani R, Soloveva V, Haddow AD, Nasar F, Bavari S, Bassik MC, Cohen SN, Levitin A, Martchenko M.Sci Rep. 2016 Sep 30;6:34475. doi: 10.1038/srep34475. PMID: 27686742 Free PMC Article3:Assessment of the antitumor potential of Bithionol in vivo using a xenograft model of ovarian cancer. Ayyagari VN, Johnston NA, Brard L.Anticancer Drugs. 2016 Jul;27(6):547-59. doi: 10.1097/CAD.0000000000000364. PMID: 27058706 4:Bithionol Potently Inhibits Human Soluble Adenylyl Cyclase through Binding to the Allosteric Activator Site. Kleinboelting S, Ramos-Espiritu L, Buck H, Colis L, van den Heuvel J, Glickman JF, Levin LR, Buck J, Steegborn C.J Biol Chem. 2016 Apr 29;291(18):9776-84. doi: 10.1074/jbc.M115.708255. Epub 2016 Mar 9. PMID: 26961873 Free PMC Article5:Bithionol inhibits ovarian cancer cell growth in vitro – studies on mechanism(s) of action. Ayyagari VN, Brard L.BMC Cancer. 2014 Feb 4;14:61. doi: 10.1186/1471-2407-14-61. PMID: 24495391 Free PMC Article6:An improved thyroid hormone reporter assay to determine the thyroid hormone-like activity of amiodarone, bithionol, closantel and rafoxanide. Matsubara K, Sanoh S, Ohta S, Kitamura S, Sugihara K, Fujimoto N.Toxicol Lett. 2012 Jan 5;208(1):30-5. doi: 10.1016/j.toxlet.2011.10.004. Epub 2011 Oct 13. PMID: 22015988 7:In vitro toxicity of bithionol and bithionol sulphoxide to Neoparamoeba spp., the causative agent of amoebic gill disease (AGD). Florent RL, Becker JA, Powell MD.Dis Aquat Organ. 2010 Sep 17;91(3):257-62. doi: 10.3354/dao02269. PMID: 21133325 Free Article8:Determination of bithionol, bromophen, nitroxynil, oxyclozanide, and tribromsalan in milk with liquid chromatography coupled with tandem mass spectrometry. Sakamoto M, Takeba K, Sasamoto T, Kusano T, Hayashi H, Kanai S, Kanda M, Nagayama T.J AOAC Int. 2010 Jul-Aug;93(4):1340-6. PMID: 20922970 9:Evaluation of marked rise in fecal egg output after bithionol administration to horse and its application as a diagnostic marker for equine Anoplocephala perfoliata infection. Sanada Y, Senba H, Mochizuki R, Arakaki H, Gotoh T, Fukumoto S, Nagahata H.J Vet Med Sci. 2009 May;71(5):617-20. PMID: 19498288 Free Article10:Further development of bithionol therapy as a treatment for amoebic gill disease in Atlantic salmon, Salmo salar L. Florent RL, Becker J, Powell MD.J Fish Dis. 2009 May;32(5):391-400. doi: 10.1111/j.1365-2761.2008.01001.x. Epub 2009 Feb 24. PMID: 19243491