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Bisdemethoxycurcumin

Bisdemethoxycurcumin

  • CAT Number: R022612
  • CAS Number: 24939-16-0
  • Molecular Formula: C19H16O4
  • Molecular Weight: 308.333
  • Purity: ≥95%
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Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α,25-<wbr></wbr>dihydroxy vitamin D<sub>3</sub> to stimulate amyloid-<wbr></wbr>β clearance by macrophages (optimal stimulation at 100 nM BDMC). More stable than curcumin in physiological media, BDMC suppresses proliferation in cancer cells. It down-<wbr></wbr>regulates the transcriptional coactivator p300, suppressing the Wnt/β-<wbr></wbr>catenin pathway, and inhibits LPS induction of iNOS expression.

Catalog Number R022612
CAS Number 24939-16-0
Molecular Formula

C19H16O4

Purity 95%
Storage -20°C
IUPAC Name (1E,6E)-1,7-bis(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione
InChI InChI=1S/C19H16O4/c20-16-7-1-14(2-8-16)5-11-18(22)13-19(23)12-6-15-3-9-17(21)10-4-15/h1-12,20-21H,13H2/b11-5+,12-6+
InChIKey PREBVFJICNPEKM-YDWXAUTNSA-N
SMILES C1=CC(=CC=C1C=CC(=O)CC(=O)C=CC2=CC=C(C=C2)O)O

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