Biphenylindanone A

• CAT Number: R015331
• CAS Number: 866823-73-6
• Molecular Formula: C30H30O4
• Molecular Weight: 454.56
• Purity: ≥95%
• Synonyms: 4-[3-[(2-cyclopentyl-6,7-dimethyl-1-oxo-2,3-dihydroinden-5-yl)oxymethyl]phenyl]benzoic acid
• InChI: InChI=1S/C30H30O4/c1-18-19(2)28-25(15-26(29(28)31)22-7-3-4-8-22)16-27(18)34-17-20-6-5-9-24(14-20)21-10-12-23(13-11-21)30(32)33/h5-6,9-14,16,22,26H,3-4,7-8,15,17H2,1-2H3,(H,32,33)
• InChIKey: KMKBEESNZAPKMP-UHFFFAOYSA-N
• SMILES: CC1=C(C=C2CC(C(=O)C2=C1C)C3CCCC3)OCC4=CC(=CC=C4)C5=CC=C(C=C5)C(=O)O

Biphenylindanone A (Cat No.: R015331) is a selective positive allosteric modulator of the metabotropic glutamate receptor 2 (mGluR2), a G-protein-coupled receptor involved in glutamatergic neurotransmission. It enhances receptor sensitivity to glutamate without directly activating the receptor, making it valuable in neurological and psychiatric research. BINA has shown potential in the treatment of anxiety, schizophrenia, and addiction. Its biphenyl and indanone structural components contribute to its receptor selectivity and pharmacological profile, supporting its use in studying mGluR2-targeted therapeutic strategies.

Reference

[1]. Rowe BA, et al. Transposition of three amino acids transforms the human metabotropic glutamate receptor (mGluR)-3-positive allosteric modulation site to mGluR2, and additional characterization of the mGluR2-positive allosteric modulation site. J Pharmacol
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