Biperiden Hydrochloride

• CAT Number: I000943
• CAS Number: 1235-82-1
• Molecular Formula: C21H30ClNO
• Molecular Weight: 347.92
• Purity: ≥95%
• Target: Muscarinic Receptor
• Solubility: 5 mM in water; 10 mM in DMSO
• Storage: Store at -20C
• IUPAC Name: 1-(2-bicyclo[2.2.1]hept-5-enyl)-1-phenyl-3-piperidin-1-ylpropan-1-ol;hydrochloride
• InChI: InChI=1S/C21H29NO.ClH/c23-21(19-7-3-1-4-8-19,11-14-22-12-5-2-6-13-22)20-16-17-9-10-18(20)15-17;/h1,3-4,7-10,17-18,20,23H,2,5-6,11-16H2;1H
• InChIKey: RDNLAULGBSQZMP-UHFFFAOYSA-N
• SMILES: C1CCN(CC1)CCC(C2CC3CC2C=C3)(C4=CC=CC=C4)O.Cl

Biperiden hydrochloride(CAT: I000943) is an anticholinergic drug used primarily in the treatment of Parkinson’s disease and drug-induced extrapyramidal symptoms. It belongs to the class of anticholinergic agents known as antiparkinsonian drugs. Biperiden hydrochloride exerts its pharmacological effects by blocking the action of acetylcholine in the central nervous system, specifically at muscarinic receptors. By inhibiting excessive cholinergic activity, it helps to alleviate symptoms such as tremors, muscle stiffness, and involuntary movements associated with Parkinson’s disease and certain medication side effects.

Reference

[1]. Pehl C, et al. Effects of two anticholinergic drugs, trospium chloride and biperiden, on motility and evoked potentials of the oesophagus. Aliment Pharmacol Ther. 1998 Oct;12(10)
[2]. Kornhuber J, et al. Identification of novel functional inhibitors of acid sphingomyelinase. PLoS One. 2011;6(8)
[3]. Myhrer T, et al. Antiparkinson drugs used as prophylactics for nerve agents: studies of cognitive side effects in rats. Pharmacol Biochem Behav. 2008 Jun;89(4):633-8.