Bioymifi

• CAT Number: I005767
• CAS Number: 1420071-30-2
• Molecular Formula: C22H12BrN3O4S
• Molecular Weight: 494.3
• Purity: ≥95%
• Target: TNF-α
• Solubility: DMSO: soluble2 mg/mL, clear (warmed)
• Storage: 2-8°C
• InChI: InChI=1S/C22H12BrN3O4S/c23-12-2-4-13(5-3-12)26-21(29)18(31-22(26)24)10-14-6-8-17(30-14)11-1-7-15-16(9-11)20(28)25-19(15)27/h1-10,24H,(H,25,27,28)/b18-10-,24-22?
• InChIKey: ULBOWKXOFOTCMU-NLDKGBHCSA-N
• SMILES: BrC(C=C1)=CC=C1N2C(S/C(C2=O)=CC3=CC=C(C4=CC=C(C(NC5=O)=O)C5=C4)O3)=N

Bioymifi (CAT: I005767) is a novel and potent small-molecule activator of the TRAIL receptor DR5 in human cancer cells. It exhibits the ability to promote cell death without the need for the Smac mimetic in T98G cells. At a concentration of 10 μM, Bioymifi induces the processing of caspase-3 into smaller fragments, and this caspase-mediated cleavage is inhibited by Z-VAD. In T98G cells, caspase-3 is rapidly activated as early as 2 hours after Bioymifi treatment, and its activity is significantly increased after 8 hours of treatment. Furthermore, Bioymifi induces caspase-8-dependent apoptosis.

Reference

[1]. Wang G, et al. Small-molecule activation of the TRAIL receptor DR5 in human cancer cells. Nat Chem Biol. 2013 Feb;9(2):84-9.