Biotin (Vitamin B7)

  • CAT Number: A001012
  • CAS Number: 58-85-5
  • Molecular Formula: C10H16N2O3S
  • Molecular Weight: 244.3
  • Purity: ≥95%
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Biotin (Cat.No:A001012), also known as vitamin H or coenzyme R, is a water-soluble B-vitamin (vitamin B7). It is composed of a ureido (tetrahydroimidizalone) ring fused with a tetrahydrothiophene ring. A valeric acid substituent is attached to one of the carbon atoms of the tetrahydrothiophene ring. Biotin is a coenzyme for carboxylase enzymes, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis.

Catalog Number A001012
CAS Number 58-85-5
Molecular Formula

C10H16N2O3S

Purity 95%
Storage -20°C
InChI 1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1
InChIKey YBJHBAHKTGYVGT-ZKWXMUAHSA-N
SMILES C1C2C(C(S1)CCCCC(=O)O)NC(=O)N2
Reference

1: Arya VB, Ajzensztejn M, Appleby G, Oddy S, Halsall D, Chatterjee K, Moran C,
Hulse T. High-dose Biotin in Infants Mimics Biochemical Hyperthyroidism with Some
Commercial Assays. Clin Endocrinol (Oxf). 2018 Jan 5. doi: 10.1111/cen.13547.
[Epub ahead of print] PubMed PMID: 29314108.
<br>

2: Xu X, Singh A, Sun Z, Ansari KR, Lin Y. Theoretical, thermodynamic and
electrochemical analysis of biotin drug as an impending corrosion inhibitor for
mild steel in 15% hydrochloric acid. R Soc Open Sci. 2017 Dec 6;4(12):170933.
doi: 10.1098/rsos.170933. eCollection 2017 Dec. PubMed PMID: 29308235; PubMed
Central PMCID: PMC5750002.

<br>
3: Anabuki T, Tsukahara M, Okamoto M, Matsuura H, Takahashi K. Novel biotin
linker with alkyne and amino groups for chemical labelling of a target protein of
a bioactive small molecule. Bioorg Med Chem Lett. 2017 Dec 26. pii:
S0960-894X(17)31229-5. doi: 10.1016/j.bmcl.2017.12.055. [Epub ahead of print]
PubMed PMID: 29306572.
<br>

4: Popova TV, Khan H, Chubarov AS, Lisitskiy VA, Antonova NM, Akulov AE, Shevelev
OB, Zavjalov EL, Silnikov VN, Ahmad S, Godovikova TS. Biotin-decorated
anti-cancer nucleotide theranostic conjugate of human serum albumin: Where the
seed meets the soil? Bioorg Med Chem Lett. 2017 Dec 26. pii:
S0960-894X(17)31235-0. doi: 10.1016/j.bmcl.2017.12.061. [Epub ahead of print]
PubMed PMID: 29305188.
<br>

5: Lohmueller JJ, Ham JD, Kvorjak M, Finn OJ. mSA2 affinity-enhanced
biotin-binding CAR T cells for universal tumor targeting. Oncoimmunology. 2017
Oct 26;7(1):e1368604. doi: 10.1080/2162402X.2017.1368604. eCollection 2017.
PubMed PMID: 29296519; PubMed Central PMCID: PMC5739565.
<br>

6: Yoon JG, Hwang HJ, Cho JA. Application of the biotin-labeled toxin mutant for
affinity isolation of associated proteins in the mammalian cells. J Biosci
Bioeng. 2017 Dec 29. pii: S1389-1723(17)30984-2. doi:
10.1016/j.jbiosc.2017.12.002. [Epub ahead of print] PubMed PMID: 29291913.

<br>
7: Abdel-Daim A, Ohura K, Imai T. A novel quantification method for serine
hydrolases in cellular expression system using fluorophosphonate-biotin probe.
Eur J Pharm Sci. 2017 Dec 28;114:267-274. doi: 10.1016/j.ejps.2017.12.016. [Epub
ahead of print] PubMed PMID: 29289670.
<br>

8: Denimal D, Nguyen A, Fromont A, Moreau T, Vergès B, Duvillard L.
[Interferences of biotin therapy on immunoassays: It is time for a long-term
solution!]. Presse Med. 2017 Dec 20. pii: S0755-4982(17)30461-X. doi:
10.1016/j.lpm.2017.09.027. [Epub ahead of print] French. PubMed PMID: 29275027.

<br>
9: Zhang X, Zhuang H. A Biotin-streptavidin-enhanced Carbon Nanotube
Amplification Strategy for an Ultrasensitive Immunodetection of Polybrominated
Diphenyl Ethers. Anal Sci. 2017;33(12):1441-1446. doi: 10.2116/analsci.33.1441.
PubMed PMID: 29225237.
<br>

10: Takayama Y, Kusamori K, Hayashi M, Tanabe N, Matsuura S, Tsujimura M, Katsumi
H, Sakane T, Nishikawa M, Yamamoto A. Long-term drug modification to the surface
of mesenchymal stem cells by the avidin-biotin complex method. Sci Rep. 2017 Dec
5;7(1):16953. doi: 10.1038/s41598-017-17166-8. PubMed PMID: 29208980; PubMed
Central PMCID: PMC5717103.

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