Biotin-PEG4-MeTz

• CAT Number: I042586
• CAS Number: 1962919-31-8
• Molecular Formula: C31H46N8O7S
• Molecular Weight: 674.81
• Purity: ≥95%
• Synonyms: 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[2-[2-[2-[2-[3-[[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methylamino]-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethyl]pentanamide
• InChI: InChI=1S/C31H46N8O7S/c1-22-36-38-30(39-37-22)24-8-6-23(7-9-24)20-33-28(41)10-12-43-14-16-45-18-19-46-17-15-44-13-11-32-27(40)5-3-2-4-26-29-25(21-47-26)34-31(42)35-29/h6-9,25-26,29H,2-5,10-21H2,1H3,(H,32,40)(H,33,41)(H2,34,35,42)/t25-,26-,29-/m0/s1
• InChIKey: FVPKDWZJCYTWCS-ZEZDXWPOSA-N
• SMILES: CC1=NN=C(N=N1)C2=CC=C(C=C2)CNC(=O)CCOCCOCCOCCOCCNC(=O)CCCCC3C4C(CS3)NC(=O)N4

Biotin-PEG4-MeTz (Cat No.: I042586) is a multifunctional chemical probe that combines a biotin tag with a polyethylene glycol (PEG4) spacer and a methyl tetrazine (MeTz) moiety for bioorthogonal click chemistry. The biotin allows affinity-based detection or purification via streptavidin binding, while the MeTz group enables rapid, catalyst-free inverse electron-demand Diels–Alder (IEDDA) reactions with trans-cyclooctene (TCO) conjugates. Biotin-PEG4-MeTz is ideal for applications in protein labeling, imaging, and target enrichment, offering high specificity, water solubility, and compatibility with live-cell or in vivo studies.

Reference

[1]. Kitowski A, et al. A Sweet Galactose Transfer: Metabolic Oligosaccharide Engineering as a Tool To Study Glycans in Plasmodium Infection. Chembiochem. 2020 Sep 14;21(18):2696-2700.
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