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BioE-1115

BioE-1115

  • CAT Number: I017781
  • CAS Number: 1268863-35-9
  • Molecular Formula: C₁₉H₁₈FN₃O₂
  • Molecular Weight: 339.36
  • Purity: ≥95%
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BioE-1115 (CAT: I017781) is a highly selective and potent inhibitor of PAS kinase (PASK) and casein kinase 2α. It exhibits an IC50 of approximately 4 nM against PASK and around 10 μM against casein kinase 2α. In cellular studies, BioE-1115 reduces PASK phosphorylation and suppresses SREBP activity, a key regulator of lipid metabolism, in a dose-dependent manner. Animal studies demonstrate that BioE-1115 administration leads to the suppression of SREBP-1c target genes, decreased insulin resistance, hepatic and serum triglycerides, and serum glucose levels. BioE-1115 shows potential as a therapeutic agent for conditions involving dysregulated lipid metabolism and insulin resistance.

Catalog Number I017781
CAS Number 1268863-35-9
Molecular Formula

C₁₉H₁₈FN₃O₂

Purity 95%
Reference

[1]. Wu X, et al. PAS kinase drives lipogenesis through SREBP-1 maturation. Cell Rep. 2014 Jul 10;8(1):242-55.

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