Bigelovin

• CAT Number: I014815
• CAS Number: 3668-14-2
• Molecular Formula: C₁₇H₂₀O₅
• Molecular Weight: 304.34
• Purity: ≥95%
• Storage: 4°C, protect from light
• IUPAC Name: [(3aS,5R,5aR,8aR,9S,9aR)-5,8a-dimethyl-1-methylidene-2,8-dioxo-3a,4,5,5a,9,9a-hexahydroazuleno[6,5-b]furan-9-yl] acetate
• InChI: InChI=1S/C17H20O5/c1-8-7-12-14(9(2)16(20)22-12)15(21-10(3)18)17(4)11(8)5-6-13(17)19/h5-6,8,11-12,14-15H,2,7H2,1,3-4H3/t8-,11+,12+,14-,15+,17+/m1/s1
• InChIKey: DCNRYQODUSSOKC-MMLVVLEOSA-N
• SMILES: CC1CC2C(C(C3(C1C=CC3=O)C)OC(=O)C)C(=C)C(=O)O2

Bigelovin（Cat No.:I014815） is a sesquiterpene lactone found in crinoids and acts as a selective agonist of retinoid X receptor α (RXRα). It exhibits antitumor effects through the induction of apoptosis and autophagy. Bigelovin also regulates the mTOR signaling pathway by inhibiting the production of reactive oxygen species (ROS). This compound holds potential for therapeutic applications in cancer treatment, but further research is needed to explore its mechanisms of action and evaluate its efficacy in clinical settings.

Reference

[1]. Bei Wang, et al. Bigelovin, a sesquiterpene lactone, suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation in liver cancer. Biochem Biophys Res Commun. 2018 May 5;499(2):156-163.