Bictegravir

  • CAT Number: I004238
  • CAS Number: 1611493-60-7
  • Molecular Formula: C21H18F3N3O5
  • Molecular Weight: 449.3862
  • Purity: ≥95%
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Bictegravir(CAT: I004238) also known as GS-9883, is a potent, unboosted, once-Daily HIV-1 Integrase Strand Transfer Inhibitor (INSTI) with improved pharmacokinetics and in vitro resistance profile. Bictegravir is currently in Phase 3 trials. This product is used for medical research and development.

Catalog Number I004238
CAS Number 1611493-60-7
Synonyms

GS-9883; GS 9883; GS9883; GS-9883-01; Bictegravir;(2R,5S,13aR)-8-hydroxy-7,9-dioxo-N-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1/’,2/’:4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide

Molecular Formula

C21H18F3N3O5

Purity 95%
Target HIV-1 Integrase Strand Transfer Inhibitor
Solubility Soluble in DMSO
Storage 0 - 4 °C for short term or -20 °C for long term
IUPAC Name (1S,11R,13R)-5-hydroxy-3,6-dioxo-N-[(2,4,6-trifluorophenyl)methyl]-12-oxa-2,9-diazatetracyclo[11.2.1.02,11.04,9]hexadeca-4,7-diene-7-carboxamide
InChI InChI=1S/C21H18F3N3O5/c22-9-3-14(23)12(15(24)4-9)6-25-20(30)13-7-26-8-16-27(10-1-2-11(5-10)32-16)21(31)17(26)19(29)18(13)28/h3-4,7,10-11,16,29H,1-2,5-6,8H2,(H,25,30)/t10-,11+,16+/m0/s1
InChIKey SOLUWJRYJLAZCX-LYOVBCGYSA-N
SMILES O=C(C1=CN(C2=C(O)C1=O)C[C@@]3([H])O[C@](C4)([H])CC[C@]4([H])N3C2=O)NCC5=C(F)C=C(F)C=C5F
Reference

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1:Bictegravir versus dolutegravir, each with emtricitabine and tenofovir alafenamide, for initial treatment of HIV-1 infection: a randomised, double-blind, phase 2 trial. Sax PE, DeJesus E, Crofoot G, Ward D, Benson P, Dretler R, Mills A, Brinson C, Peloquin J, Wei X, White K, Cheng A, Martin H, Quirk E.Lancet HIV. 2017 Apr;4(4):e154-e160. doi: 10.1016/S2352-3018(17)30016-4. Epub 2017 Feb 15. PMID: 28219610<br />
2:Antiviral Activity, Safety, and Pharmacokinetics of Bictegravir as 10-Day Monotherapy in HIV-1-Infected Adults. Gallant JE, Thompson M, DeJesus E, Voskuhl GW, Wei X, Zhang H, White K, Cheng A, Quirk E, Martin H.J Acquir Immune Defic Syndr. 2017 May 1;75(1):61-66. doi: 10.1097/QAI.0000000000001306. PMID: 28196003 Free PMC Article<br />
3:Antiviral Activity of Bictegravir (GS-9883), a Novel Potent HIV-1 Integrase Strand Transfer Inhibitor with an Improved Resistance Profile. Tsiang M, Jones GS, Goldsmith J, Mulato A, Hansen D, Kan E, Tsai L, Bam RA, Stepan G, Stray KM, Niedziela-Majka A, Yant SR, Yu H, Kukolj G, Cihlar T, Lazerwith SE, White KL, Jin H.Antimicrob Agents Chemother. 2016 Nov 21;60(12):7086-7097. Print 2016 Dec. PMID: 27645238 Free PMC Article

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