For research use only. Not for therapeutic Use.
BI 99179(CAT: I017212) is a potent and selective type I fatty acid synthase (FAS) inhibitor with an IC₅₀ of 79 nM, making it a valuable tool compound for validating FAS as a therapeutic target in lipid metabolism-related diseases. It demonstrates strong activity in mouse hypothalamic N-42 cells (IC₅₀ = 0.6 μM) without cytotoxicity up to 30 μM. BI 99179 exhibits antiproliferative effects in human glioma GAMG cells and shows excellent pharmacokinetic properties in rats (t₁/₂ = 3.0 h; oral 4 mg/kg), with both peripheral and central exposure. Its potency and selectivity support applications in metabolic and oncology research.
| CAS Number | 1291779-76-4 |
| Synonyms | (1R,3S)-N-[4-(1,3-benzoxazol-2-yl)phenyl]-N-methyl-3-(propanoylamino)cyclopentane-1-carboxamide |
| Molecular Formula | C23H25N3O3 |
| Purity | ≥95% |
| IUPAC Name | (1R,3S)-N-[4-(1,3-benzoxazol-2-yl)phenyl]-N-methyl-3-(propanoylamino)cyclopentane-1-carboxamide |
| InChI | InChI=1S/C23H25N3O3/c1-3-21(27)24-17-11-8-16(14-17)23(28)26(2)18-12-9-15(10-13-18)22-25-19-6-4-5-7-20(19)29-22/h4-7,9-10,12-13,16-17H,3,8,11,14H2,1-2H3,(H,24,27)/t16-,17+/m1/s1 |
| InChIKey | YNFDIGJKJPNFFD-SJORKVTESA-N |
| SMILES | CCC(=O)NC1CCC(C1)C(=O)N(C)C2=CC=C(C=C2)C3=NC4=CC=CC=C4O3 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
