BGC-20-1531 free base

• CAT Number: I045050
• CAS Number: 736183-35-0
• Molecular Formula: C26H24N2O6S
• Molecular Weight: 492.54
• Purity: ≥95%
• Synonyms: 4-[[4-(5-methoxypyridin-2-yl)phenoxy]methyl]-5-methyl-N-(2-methylphenyl)sulfonylfuran-2-carboxamide
• InChI: InChI=1S/C26H24N2O6S/c1-17-6-4-5-7-25(17)35(30,31)28-26(29)24-14-20(18(2)34-24)16-33-21-10-8-19(9-11-21)23-13-12-22(32-3)15-27-23/h4-15H,16H2,1-3H3,(H,28,29)
• InChIKey: IXDVRRPNWPOPGV-UHFFFAOYSA-N
• SMILES: CC1=CC=CC=C1S(=O)(=O)NC(=O)C2=CC(=C(O2)C)COC3=CC=C(C=C3)C4=NC=C(C=C4)OC

BGC-20-1531 free base（Cat No.:I045050）is a highly selective and potent antagonist of the prostaglandin E₂ receptor subtype EP4. With nanomolar affinity (Kᵢ ~3 nM), it exhibits over 2500-fold selectivity over EP₂ and EP₃ receptors. This compound effectively inhibits PGE₂-induced vasodilation in human cerebral and meningeal arteries, making it a valuable tool in migraine and neurovascular research. It does not affect other vascular beds like coronary or renal arteries. BGC-20-1531 is used in preclinical studies to investigate inflammatory and pain pathways mediated by EP4 signaling, particularly in headache and neuroinflammation models.