CONTACT US
Home > Inhibitors/Agonists>PROTACs> > BETd-260
BETd-260

BETd-260

  • CAT Number: I020058
  • CAS Number: 2093388-62-4
  • Molecular Formula: C₄₃H₄₆N₁₀O₆
  • Molecular Weight: 798.89
  • Purity: ≥95%
Inquiry Now

BETd-260 (CAT: I020058), also known as ZBC 260, is a potent PROTAC BET degrader with exceptional activity against BRD4 protein in RS4;11 leukemia cells (IC50 as low as 30 pM). It effectively suppresses cell viability and induces apoptosis in hepatocellular carcinoma (HCC) cells. BETd-260 induces degradation of BRD2, BRD3, and BRD4 proteins in leukemia cells, inhibits leukemia cell growth (IC50 51 pM), and promotes apoptosis. It modulates the expression of apoptotic genes and causes rapid tumor regression (over 90% regression) in RS4;11 xenograft mice models. BETd-260 shows promise as a therapeutic agent for leukemia and hepatocellular carcinoma.

Catalog Number I020058
CAS Number 2093388-62-4
Molecular Formula

C₄₃H₄₆N₁₀O₆

Purity 95%
Reference

[1]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.<br>[2]. Zhang H, et al. Targeting BET Proteins With a PROTAC Molecule Elicits Potent Anticancer Activity in HCC Cells. Front Oncol. 2020;9:1471. Published 2020 Jan 14.

Request a Quote

Contact Us at MuseChem

We are committed to providing you with reliable, cost-effective solutions for your chemical needs, while ensuring your safety and comfort. Our team of experts is always available to answer your questions and help you navigate the complexities of the chemical industry.

Whether you're looking for a specific product or need help with a custom synthesis project, we're here to help you discover a new world of chemical possibilities. Contact us today to learn more about how we can assist you with all of your chemical needs.

Our goal is to make the process of ordering chemicals as seamless and hassle-free as possible. Let us know how we can assist you, and we'll get back to you as soon as possible. We look forward to hearing from you!