For research use only. Not for therapeutic Use.
BET-IN-19(CAT: I040634) is a potent and selective inhibitor of BET (bromodomain and extra-terminal domain) proteins, which play a critical role in regulating gene expression through recognition of acetylated lysine residues on histones. By targeting BRD2, BRD3, and BRD4, BET-IN-19 disrupts the recruitment of transcriptional machinery to chromatin, making it a valuable tool in epigenetic research and cancer biology. It is particularly useful for studying transcriptional regulation, inflammatory pathways, and oncogenic drivers such as MYC. BET-IN-19 has shown promising effects in preclinical models of leukemia, lymphoma, and solid tumors.
| CAS Number | 1643947-30-1 |
| Synonyms | 1-benzyl-6-(3,5-dimethyl-1,2-oxazol-4-yl)-N-methylimidazo[4,5-b]pyridin-2-amine |
| Molecular Formula | C19H19N5O |
| Purity | ≥95% |
| IUPAC Name | 1-benzyl-6-(3,5-dimethyl-1,2-oxazol-4-yl)-N-methylimidazo[4,5-b]pyridin-2-amine |
| InChI | InChI=1S/C19H19N5O/c1-12-17(13(2)25-23-12)15-9-16-18(21-10-15)22-19(20-3)24(16)11-14-7-5-4-6-8-14/h4-10H,11H2,1-3H3,(H,20,21,22) |
| InChIKey | VUFGOHIETLJZRG-UHFFFAOYSA-N |
| SMILES | CC1=C(C(=NO1)C)C2=CC3=C(N=C2)N=C(N3CC4=CC=CC=C4)NC |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
