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dBRD9 - CAS 2170679-45-3

dBRD9 (CAT: I025588) is a small molecule that acts as a PROTAC (PROteolysis TArgeting Chimera) degrader. It is designed to target and degrade the BRD9 bromodomain protein by recruiting it to the cereblon E3 ubiquitin ligase complex. This mechanism of action leads to the ubiquitination and subsequent degradation of BRD9, resulting in the downregulation of its biological activity. dBRD9 and other PROTACs are being investigated as novel approaches for targeted protein degradation in drug discovery and development.

Catalog Number: I025588

CAS Number: 2170679-45-3

Molecular Formula: C40H45N7O10

Molecular Weight:783.84

Purity: 98.0%

Appearance:Solid powder

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* For research use only. Not for human or veterinary use.

Synonym

SynonymsdBRD-9; dBRD 9; dBRD9

Property

Molecular Formula: C40H45N7O10
Molecular Weight783.84
SolubilitySoluble in DMSO
Purity98.0%
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Computed Descriptor

IUPAC Name2-((2,6-Dimethoxy-4-(2-methyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)benzyl)(methyl)amino)-N-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethyl)acetamide
InChIInChI=1S/C40H45N7O10/c1-45(21-29-32(54-3)18-24(19-33(29)55-4)28-22-46(2)38(51)27-20-41-11-10-25(27)28)23-35(49)43-13-15-57-17-16-56-14-12-42-30-7-5-6-26-36(30)40(53)47(39(26)52)31-8-9-34(48)44-37(31)50/h5-7,10-11,18-20,22,31,42H,8-9,12-17,21,23H2,1-4H3,(H,43,49)(H,44,48,50)
InChIKeyAIOCFZJGGGEWDK-UHFFFAOYSA-N
SMILESO=C(NCCOCCOCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CN(CC4=C(OC)C=C(C(C5=CC=NC=C65)=CN(C)C6=O)C=C4OC)C