• CAT Number: I025588
  • CAS Number: 2170679-45-3
  • Molecular Formula: C40H45N7O10
  • Molecular Weight: 783.84
  • Purity: 98%
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dBRD9 (CAT: I025588) is a small molecule that acts as a PROTAC (PROteolysis TArgeting Chimera) degrader. It is designed to target and degrade the BRD9 bromodomain protein by recruiting it to the cereblon E3 ubiquitin ligase complex. This mechanism of action leads to the ubiquitination and subsequent degradation of BRD9, resulting in the downregulation of its biological activity. dBRD9 and other PROTACs are being investigated as novel approaches for targeted protein degradation in drug discovery and development.

Catalog Number I025588
CAS Number 2170679-45-3

dBRD-9; dBRD 9; dBRD9

Molecular Formula


Purity 98
Solubility Soluble in DMSO
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
IUPAC Name 2-((2,6-Dimethoxy-4-(2-methyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)benzyl)(methyl)amino)-N-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethyl)acetamide
InChI InChI=1S/C40H45N7O10/c1-45(21-29-32(54-3)18-24(19-33(29)55-4)28-22-46(2)38(51)27-20-41-11-10-25(27)28)23-35(49)43-13-15-57-17-16-56-14-12-42-30-7-5-6-26-36(30)40(53)47(39(26)52)31-8-9-34(48)44-37(31)50/h5-7,10-11,18-20,22,31,42H,8-9,12-17,21,23H2,1-4H3,(H,43,49)(H,44,48,50)

1: Remillard D, Buckley DL, Paulk J, Brien GL, Sonnett M, Seo HS, Dastjerdi S, Wühr M, Dhe-Paganon S, Armstrong SA, Bradner JE. Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands. Angew Chem Int Ed Engl. 2017 May 15;56(21):5738-5743. doi: 10.1002/anie.201611281. Epub 2017 Apr 18. PubMed PMID: 28418626; PubMed Central PMCID: PMC5967236.

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