Berbamine

• CAT Number: R035310
• CAS Number: 478-61-5
• Molecular Formula: C37H40N2O6
• Molecular Weight: 608.7
• Purity: ≥95%
• Storage: Store at -20°C, protect from light
• IUPAC Name: (1S,14R)-20,21,25-trimethoxy-15,30-dimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.23,6.18,12.114,18.027,31.022,33]hexatriaconta-3(36),4,6(35),8,10,12(34),18,20,22(33),24,26,31-dodecaen-9-ol
• InChI: InChI=1S/C37H40N2O6/c1-38-14-12-24-19-32(41-3)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-31-18-23(8-11-30(31)40)17-29-35-25(13-15-39(29)2)20-34(42-4)36(43-5)37(35)45-33/h6-11,18-21,28-29,40H,12-17H2,1-5H3/t28-,29+/m0/s1
• InChIKey: DFOCUWZXJBAUSQ-URLMMPGGSA-N
• SMILES: CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)O)OC

Berbamine (Cat No.:R035310) is a natural compound belonging to the bisbenzylisoquinoline class. It is extracted from Prunus chinensis, a Chinese herbal medicine. Berbamine exhibits several pharmacological activities, including being a novel inhibitor of bcr/abl, a potent anti-leukemic agent, and an inhibitor of NF-κB. It suppresses cancer cell growth and induces apoptosis in human myeloma cells by targeting Ca²⁺/calmodulin-dependent protein kinase II (CaMKII). These findings highlight the potential of berbamine as a therapeutic agent in cancer treatment.