Berbamine dihydrochloride

• CAT Number: I004291
• CAS Number: 6078-17-7
• Molecular Formula: C₃₇H₄₂Cl₂N₂O₆
• Molecular Weight: 681.65
• Purity: ≥95%
• Solubility: 10 mM in DMSO
• Storage: 3 years -20℃ powder
• IUPAC Name: (1S,14R)-20,21,25-trimethoxy-15,30-dimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.23,6.18,12.114,18.027,31.022,33]hexatriaconta-3(36),4,6(35),8,10,12(34),18,20,22(33),24,26,31-dodecaen-9-ol;dihydrochloride
• InChI: InChI=1S/C37H40N2O6.2ClH/c1-38-14-12-24-19-32(41-3)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-31-18-23(8-11-30(31)40)17-29-35-25(13-15-39(29)2)20-34(42-4)36(43-5)37(35)45-33;;/h6-11,18-21,28-29,40H,12-17H2,1-5H3;2*1H/t28-,29+;;/m0../s1
• InChIKey: USRXDYNDPPUBSG-KKXMJGKMSA-N
• SMILES: CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)O)OC.Cl.Cl

Berbamine dihydrochloride (Cat.No:I004291) is a natural compound derived from the roots of the plant Berberis amurensis. It has been studied for its potential anti-cancer effects and has shown to inhibit the growth and proliferation of cancer cells in vitro and in vivo. Berbamine dihydrochloride is considered safe for use in traditional medicine. Further research is needed to explore its potential therapeutic applications.

Reference

[1]. Hou ZB, et al. In vitro and in vivo antitumor evaluation of berbamine for lung cancer treatment. Asian Pac J Cancer Prev. 2014;15(4):1767-9.

[2]. Jin X, et al. Berbamine enhances the antineoplastic activity of gemcitabine in pancreatic cancer cells by activating transforming growth factor-β/Smad signaling. Anat Rec (Hoboken). 2014 May;297(5):802-9.