Benzyl-PEG2-Tos

  • CAT Number: I014161
  • CAS Number: 4981-83-3
  • Molecular Formula: C16H18O4S
  • Molecular Weight: 306.38
  • Purity: ≥95%
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Benzyl-PEG2-Tos (CAT: I014161) functions as a Benzyl PEG Linker, playing a crucial role in bioconjugation strategies. Polyethylene glycol (PEG) linkers are valuable tools in the field of material chemistry, particularly in the development of antibody-drug conjugates (ADCs). These linkers act as intermediaries, covalently attaching therapeutic agents, such as drugs, to antibodies. In this context, Benzyl-PEG2-Tos serves as a versatile bridge, facilitating the controlled and targeted delivery of drugs to specific cells or tissues.

Catalog Number I014161
CAS Number 4981-83-3
Molecular Formula

C16H18O4S

Purity 95%
Solubility Soluble in DMSO
InChI InChI=1S/C16H18O4S/c1-14-7-9-16(10-8-14)21(17,18)20-12-11-19-13-15-5-3-2-4-6-15/h2-10H,11-13H2,1H3
InChIKey HFNFGZWMDNDYNJ-UHFFFAOYSA-N
SMILES CC(C=C1)=CC=C1S(OCCOCC2=CC=CC=C2)(=O)=O
Reference

</br>1: Kim HJ, Miyata K, Nomoto T, Zheng M, Kim A, Liu X, Cabral H, Christie RJ, Nishiyama N, Kataoka K. siRNA delivery from triblock copolymer micelles with spatially-ordered compartments of PEG shell, siRNA-loaded intermediate layer, and hydrophobic core. Biomaterials. 2014 May;35(15):4548-56. doi: 10.1016/j.biomaterials.2014.02.016. Epub 2014 Mar 6. PubMed PMID: 24613051.</br>2: Acton AL, Fante C, Flatley B, Burattini S, Hamley IW, Wang Z, Greco F, Hayes W. Janus PEG-based dendrimers for use in combination therapy: controlled multi-drug loading and sequential release. Biomacromolecules. 2013 Feb 11;14(2):564-74. doi: 10.1021/bm301881h. Epub 2013 Jan 18. PubMed PMID: 23305104.</br>3: Mueller C, Capelle MA, Seyrek E, Martel S, Carrupt PA, Arvinte T, Borchard G. Noncovalent PEGylation: different effects of dansyl-, L-tryptophan-, phenylbutylamino-, benzyl- and cholesteryl-PEGs on the aggregation of salmon calcitonin and lysozyme. J Pharm Sci. 2012 Jun;101(6):1995-2008. doi: 10.1002/jps.23110. Epub 2012 Mar 23. PubMed PMID: 22447529. </br> </br>

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