Bentiromide

• CAT Number: I002811
• CAS Number: 37106-97-1
• Molecular Formula: C23H20N2O5
• Molecular Weight: 404.422
• Purity: ≥95%
• Synonyms: Bentiromide; Bentiromido; Bentiromidum; CHEBI:31263; 37106-97-1; PFT; BTPABA; PFT;4-[2-benzamido-3- (4-hydroxyphenyl)- propanoyl] aminobenzoic acid
• IUPAC Name: 4-[[(2S)-2-benzamido-3-(4-hydroxyphenyl)propanoyl]amino]benzoic acid
• InChI: InChI=1S/C23H20N2O5/c26-19-12-6-15(7-13-19)14-20(25-21(27)16-4-2-1-3-5-16)22(28)24-18-10-8-17(9-11-18)23(29)30/h1-13,20,26H,14H2,(H,24,28)(H,25,27)(H,29,30)/t20-/m0/s1
• InChIKey: SPPTWHFVYKCNNK-FQEVSTJZSA-N
• SMILES: C1=CC=C(C=C1)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3=CC=C(C=C3)C(=O)O

Bentiromide is a peptide used as a screening test for exocrine pancreatic insufficiency and to monitor the adequacy of supplemental pancreatic therapy. It is given by mouth as a noninvasive test. The amount of 4-aminobenzoic acid and its metabolites excreted in the urine is taken as a measure of the chymotrypsin-secreting activity of the pancreas.

Reference

1:The assessment of pancreatic exocrine function by bentiromide test in patients with chronic portal vein thrombosis. Egesel T, Unsal I, Dikmen G, Bayraktar Y.Pancreas. 2002 Nov;25(4):355-9. PMID: 12409829 2:Comparative study of bentiromide test and endoscopic retrograde pancreatography in patients with chronic pancreatitis. Chung JB, Park SW, Song SY, Moon YM, Kang JK, Park IS.Yonsei Med J. 1998 Feb;39(1):45-9. PMID: 9529984 Free Article3:[PFD test (bentiromide test, BT-PABA test)]. Oyama H, Watanabe S.Nihon Rinsho. 1997 Apr;55 Suppl 2:202-5. Review. Japanese. No abstract available. PMID: 9172506 4:Bentiromide test using liquid-chromatographic measurement of p-aminobenzoic acid and its metabolites for diagnosing pancreatic insufficiency in childhood. Durie PR, Yung-Jato LY, Soldin SJ, Verjee Z, Ellis L.J Pediatr. 1992 Sep;121(3):413-6. PMID: 1517919 5:The bentiromide test using plasma p-aminobenzoic acid for diagnosing pancreatic insufficiency in young children. The effect of two different doses and a liquid meal. Laufer D, Cleghorn G, Forstner G, Ellis L, Koren G, Durie P.Gastroenterology. 1991 Jul;101(1):207-13. PMID: 2044909 6:The development of the chymotryptic activity during postnatal life using the bentiromide test. Bujanover Y, Harel A, Geter R, Blau H, Yahav J, Spirer Z.Int J Pancreatol. 1988 Jan-Feb;3(1):53-8. PMID: 3258344 7:Bentiromide test is not affected in patients with small bowel disease or liver disease. Meyer BM, Campbell DR, Curington CW, Toskes PP.Pancreas. 1987;2(1):44-7. PMID: 3494995 8:Exocrine pancreatic function as determined in a same-day test with use of bentiromide and p-aminosalicylic acid. Berg JD, Chesner IM, Allen-Narker RA, Buckley BM, Lawson N.Clin Chem. 1986 Jun;32(6):1010-2. PMID: 3486726 Free Article9:Digestion of bentiromide and absorption of xylose in healthy cats and absorption of xylose in cats with infiltrative intestinal disease. Hawkins EC, Meric SM, Washabau RJ, Feldman EC, Turrel JM.Am J Vet Res. 1986 Mar;47(3):567-9. PMID: 3485942 10:A new criterion in the assessment of bentiromide as a test of exocrine pancreatic function in alcoholics. Ertan A, Degertekin H, Akdamar K, Godiwala T, Mather F.Pancreas. 1986;1(2):176-9. PMID: 3494993