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Benorilate

Benorilate

  • CAT Number: R041630
  • CAS Number: 5003-48-5
  • Molecular Formula: C17H15NO5
  • Molecular Weight: 313.309
  • Purity: ≥95%
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Benorilate, also known as Win-11450, is an ester of aspirin and paracetamol with analgesic, antipyretic, and anti-inflammatory activity used in the treatment of rheumatoid diseases. Benorilate has less severe side effects than aspirin.

Catalog Number R041630
CAS Number 5003-48-5
Molecular Formula

C17H15NO5

Purity 95%
Storage -20°C
IUPAC Name (4-acetamidophenyl) 2-acetyloxybenzoate
InChI InChI=1S/C17H15NO5/c1-11(19)18-13-7-9-14(10-8-13)23-17(21)15-5-3-4-6-16(15)22-12(2)20/h3-10H,1-2H3,(H,18,19)
InChIKey FEJKLNWAOXSSNR-UHFFFAOYSA-N
SMILES CC(=O)NC1=CC=C(C=C1)OC(=O)C2=CC=CC=C2OC(=O)C
Reference

</br>1:Determination of benorilate in pharmaceutical formulations and its metabolite in urine at carbon paste electrode modified by silver nanoparticles. Wang CY, Hu XY.Talanta. 2005 Sep 15;67(3):625-33. doi: 10.1016/j.talanta.2005.03.009. Epub 2005 Apr 18. PMID: 18970216 </br>2:[Studies on formulation and bioavailability of benorilate tablets]. Chen J, Tu XD.Yao Xue Xue Bao. 1994;29(9):707-12. Chinese. PMID: 7900541 </br>3:Protection against paracetamol-induced glutathione depletion following a paracetamol-acetylsalicylic acid mixture or benorilate in phenobarbital-treated rats. De Vries J, Jansen JD, Kroese ED, Van Bree L, Van Ginneken CA.Toxicol Lett. 1981 Dec;9(4):345-7. No abstract available. PMID: 6120590 </br>4:Hepatotoxic metabolic activation of paracetamol and its derivatives phenacetin and benorilate: oxygenation or electron transfer? de Vries J.Biochem Pharmacol. 1981 Mar 1;30(5):399-402. No abstract available. PMID: 6112004 </br>5:[Clinical evaluation of the effectiveness of benorilate in rheumatoid arthritis in children]. Melikhova NI, Klimov IuV.Pediatriia. 1980;(9):52-3. Russian. No abstract available. PMID: 6107892 </br>6:[Clinical study of benorilate. Co-ordinated multi-centre test (author/’s transl)]. Asch L, Ayrolles C, Serratrice G, Simon L.Sem Hop. 1979 Sep 18-25;55(31-32):1395-9. French. PMID: 41323 </br>7:[Identification and quantitation of impurities from benorilate (Salipran) by high-performance liquid chromatography (author/’s transl)]. Chevalier G, Rohrbach P, Bollet C, Caude M.J Chromatogr. 1977 Aug 1;138(1):193-201. French. PMID: 19488 </br>8:[Thermographic and histologic studies of the antiinflammatory effect of benorilate by means of the cotton pellet test in the rat (author/’s transl)]. Lörincz G, Kary K.Arzneimittelforschung. 1975 Oct;25(10):1549-1. German. PMID: 1041

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