Bendazac

• CAT Number: R055266
• CAS Number: 20187-55-7
• Molecular Formula: C16H14N2O3
• Molecular Weight: 282.299
• Purity: ≥95%
• Storage: -20°C
• IUPAC Name: 2-(1-benzylindazol-3-yl)oxyacetic acid
• InChI: InChI=1S/C16H14N2O3/c19-15(20)11-21-16-13-8-4-5-9-14(13)18(17-16)10-12-6-2-1-3-7-12/h1-9H,10-11H2,(H,19,20)
• InChIKey: BYFMCKSPFYVMOU-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)CN2C3=CC=CC=C3C(=N2)OCC(=O)O

Bendazac, also known as Bendazolic acid and AF-983, is an anticataract drug. It has been reported that Bendazac acts by preventing protein denaturation.

Reference

1:Characterization of a novel process-related impurity in commercial bendazac lysine eye drops by LC-ESI-QTOF/MS/MS and NMR. Zhu P, Yang W, Hong L, Cheng Q, Luo L, He J, Chen J.J Pharm Biomed Anal. 2015 Mar 25;107:437-43. doi: 10.1016/j.jpba.2015.01.002. Epub 2015 Jan 10. PMID: 25666544 2:Synthesis and biological evaluations of novel bendazac lysine analogues as potent anticataract agents. Shen H, Gou S, Shen J, Zhu Y, Zhang Y, Chen X.Bioorg Med Chem Lett. 2010 Apr 1;20(7):2115-8. doi: 10.1016/j.bmcl.2010.02.061. Epub 2010 Feb 19. PMID: 20223660 3:Protective effects of bendazac lysine on diabetic peripheral neuropathy in streptozotocin-induced diabetic rats. Yu JX, Yin XX, Shen JP, Qiu J, Yin HL, Jiang SJ.Clin Exp Pharmacol Physiol. 2006 Dec;33(12):1231-8. PMID: 17184506 4:Protective effects of bendazac lysine on early experimental diabetic nephropathy in rats. Yin XX, Zhang YD, Shen JP, Wu HW, Zhu X, Li LM, Qiu J, Jiang SJ, Zheng XG.Acta Pharmacol Sin. 2005 Jun;26(6):721-8. PMID: 15916739 Free Article5:Bendazac lysine inhibition of human lens epithelial cell adhesion to polymethylmethacrylate intraocular lenses. Soldo L, Ruggieri A, Milanese C, Pinza M, Guglielmotti A.Ophthalmic Res. 2004 May-Jun;36(3):145-50. PMID: 15103205 6:Allergic contact dermatitis due to bendazac and alclometasone dipropionate. Iwakiri K, Hata M, Miura Y, Numano K, Yuge M, Sasaki E.Contact Dermatitis. 1999 Oct;41(4):218-39. Review. No abstract available. PMID: 10515101 7:Pharmacokinetics of bendazac lysine in 10 Chinese young men. Chen XX, Zhang YD, Shen JP, Pu J, Yan HY, Zhu YQ, Qiu JJ.Zhongguo Yao Li Xue Bao. 1997 Mar;18(2):109-11. PMID: 10072958 Free Article8:Vitreous fluorophotometry and changes in blood-retinal barrier permeability induced by bendazac lysine. Nuzzi G, Venturini I, De Gregorio M, Arsenio L, Maraini G.Acta Ophthalmol Scand. 1997 Feb;75(1):41-3. PMID: 9088399 Free Article9:Kinetics of the inhibition of xanthine dehydrogenase and of the reversible and irreversible forms of xanthine oxidase by silibinin and bendazac. Silva MP, Mira L, Lima J, Manso CF.Environ Toxicol Pharmacol. 1996 Jul 15;1(4):279-84. doi: 10.1016/1382-6689(96)00021-X. PMID: 21781693 10:Spectroscopic characterization of bendazac and benzydamine: possible photochemical modes of action. Jez JM, Vanderkooi JM, Laties AM.Biochem Biophys Res Commun. 1996 Apr 16;221(2):266-70. PMID: 8619844