BCl-2 Inhibitor GX15-070

• CAT Number: I012088
• CAS Number: 803712-67-6
• Molecular Formula: C20H19N3O
• Molecular Weight: 317.38
• Purity: ≥95%
• Synonyms: (Z)-2-(2-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl)-1H-indole methanesulfonate
• Target: A Bcl-2 inhibitor
• Solubility: DMSO (>80 mg/ml)
• Storage: -20°C
• InChI: InChI=1S/C20H19N3O.CH4O3S/c1-12-8-13(2)21-16(12)10-19-20(24-3)11-18(23-19)17-9-14-6-4-5-7-15(14)22-17;1-5(2,3)4/h4-11,21,23H,1-3H3;1H3,(H,2,3,4)/b18-17-,19-10-
• InChIKey: ZVAGBRFUYHSUHA-LZOXOEDVSA-N
• SMILES: CC1=CC(=C(N1)C=C2C(=CC(=C3C=C4C=CC=CC4=N3)N2)OC)C.CS(=O)(=O)O

BCl-2 Inhibitor GX15-070(CAT: I012088) is a small molecule pan–Bcl-2 antagonist. It is capable of mimicking the action of BH3-only proteins by binding to multiple antiapoptotic Bcl-2 family members. GX15-070 has demonstrated the ability to overcome resistance mediated by Bcl-2, Bcl-xl, Bcl-w, and Mcl-1, which are proteins involved in inhibiting cell death. It interferes with the direct interaction between Mcl-1 and Bak within the outer mitochondrial membrane and inhibits the association between Mcl-1 and Bak in intact cells. This inhibition of Bcl-2 family interactions contributes to its potential as an anti-cancer therapeutic agent.