BCI-215

• CAT Number: I017415
• CAS Number: 1245792-67-9
• Molecular Formula: C₂₂H₂₂BrNO
• Molecular Weight: 396.32
• Purity: ≥95%

BCI-215(CAT: I017415) is a potent tumor cell-selective inhibitor of dual-specificity MAPK phosphatase (DUSP-MKP). It exhibits cytotoxicity specifically towards tumor cells while sparing normal cells. By inhibiting DUSP-MKP, BCI-215 disrupts the MAPK signaling pathway, which plays a crucial role in cell growth and survival. The selective cytotoxicity of BCI-215 for tumor cells makes it a promising candidate for targeted cancer therapy, potentially minimizing side effects on normal tissues.

Reference

[1]. Korotchenko VN, et al. In vivo structure-activity relationship studies support allosteric targeting of a dual specificity phosphatase. Chembiochem. 2014 Jul 7;15(10):1436-45.[2]. Kaltenmeier CT, et al. A Tumor Cell-Selective Inhibitor of Mitogen-Activated Protein Kinase Phosphatases Sensitizes Breast Cancer Cells to Lymphokine-Activated Killer Cell Activity. J Pharmacol Exp Ther. 2017 Apr;361(1):39-50.