BC11-38

• CAT Number: I004089
• CAS Number: 686770-80-9
• Molecular Formula: C15H16N2OS2
• Molecular Weight: 304.42
• Purity: ≥95%
• Target: PDE
• Solubility: Soluble in DMSO
• Storage: Store at 4 °C
• IUPAC Name: 3-phenyl-2-propylsulfanyl-6,7-dihydrothieno[3,2-d]pyrimidin-4-one
• InChI: InChI=1S/C15H16N2OS2/c1-2-9-20-15-16-12-8-10-19-13(12)14(18)17(15)11-6-4-3-5-7-11/h3-7H,2,8-10H2,1H3
• InChIKey: YHNDCCKFNWDQGW-UHFFFAOYSA-N
• SMILES: CCCSC1=NC2=C(C(=O)N1C3=CC=CC=C3)SCC2

BC11-38 (Cat.No:I004089) is a biologically active inhibitor of PDE11 with high potency and selectivity. Its IC50 for PDE11 is 0.28 µM, whereas it is greater than 100 µM for PDE1-10. BC11-38 elevates cAMP levels, and increases PKA-mediated ATF-1 phosphorylation and cortisol production in H295R cells.

Reference

1: Qiu YL, Gong JY, Feng JY, Wang RX, Han J, Liu T, Lu Y, Li LT, Zhang MH, Sheps JA, Wang NL, Yan YY, Li JQ, Chen L, Borchers CH, Sipos B, Knisely AS, Ling V, Xing QH, Wang JS. Defects in MYO5B are associated with a spectrum of previously undiagnose