For research use only. Not for therapeutic Use.
BAZ2-ICR(CAT: I004082) is a potent, selective, and cell-active BAZ2A/B bromodomain inhibitor, with IC50 values of 130 nM (BAZ2A) and 180 nM (BAZ2B), and Kd values of 109 nM and 170 nM, respectively. It exhibits 10–15-fold selectivity over CECR2 and >100-fold selectivity versus other bromodomains, establishing it as a high-quality epigenetic chemical probe. In U2OS cells, BAZ2-ICR (1 μM) displaces BAZ2A from chromatin, confirmed by FRAP assays. The compound demonstrates excellent solubility, microsomal stability, and oral bioavailability (70% at 5 mg/kg). With robust pharmacokinetics and cell activity, BAZ2-ICR is a valuable tool for epigenetics and chromatin biology research.
| CAS Number | 1665195-94-7 |
| Synonyms | 4-[5-(1-methylpyrazol-4-yl)-3-[2-(1-methylpyrazol-4-yl)ethyl]imidazol-4-yl]benzonitrile |
| Molecular Formula | C20H19N7 |
| Purity | ≥95% |
| IUPAC Name | 4-[5-(1-methylpyrazol-4-yl)-3-[2-(1-methylpyrazol-4-yl)ethyl]imidazol-4-yl]benzonitrile |
| InChI | InChI=1S/C20H19N7/c1-25-12-16(10-23-25)7-8-27-14-22-19(18-11-24-26(2)13-18)20(27)17-5-3-15(9-21)4-6-17/h3-6,10-14H,7-8H2,1-2H3 |
| InChIKey | RRZVGDGTWNQAPW-UHFFFAOYSA-N |
| SMILES | CN1C=C(C=N1)CCN2C=NC(=C2C3=CC=C(C=C3)C#N)C4=CN(N=C4)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
