BAYK 8644

• CAT Number: I004068
• CAS Number: 71145-03-4
• Molecular Formula: C16H15F3N2O4
• Molecular Weight: 356.3
• Purity: ≥95%
• Target: Autophagy
• Solubility: Soluble in DMSO
• Storage: 2-8°C
• IUPAC Name: methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate
• InChI: InChI=1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3
• InChIKey: ZFLWDHHVRRZMEI-UHFFFAOYSA-N
• SMILES: CC1=C(C(C(=C(N1)C)[N+](=O)[O-])C2=CC=CC=C2C(F)(F)F)C(=O)OC

Bay K 8644, a L-type Ca2+ channel agonist with an EC50 of 17.3 nM, comprises two isomers: (R)-(+)-Bay-K-8644 and (S)-(-)-Bay-K-8644. It prolongs the open time of sarcolemmal Ca2+ channels, resulting in increased Ca2+ influx. Bay K 8644 also exhibits vasoconstrictive properties.

Reference

1:Effect of BayK 8644 on [Ca²⁺]i and viability in PC3 human prostate cancer cells. Lai ZR, Chou CT, Liu SI, Liang WZ, Huang JK, Jan CR.Chin J Physiol. 2013 Dec 31;56(6):318-25. doi: 10.4077/CJP.2013.BAB161. Erratum in: Chin J Physiol. 2014 Feb 28;57(1):60. PMID: 24495178 2:Conformational changes induced in voltage-gated calcium channel Cav1.2 by BayK 8644 or FPL64176 modify the kinetics of secretion independently of Ca2+ influx. Marom M, Hagalili Y, Sebag A, Tzvier L, Atlas D.J Biol Chem. 2010 Mar 5;285(10):6996-7005. doi: 10.1074/jbc.M109.059865. Epub 2010 Jan 6. PMID: 20054004 Free PMC Article3:NMDAR blockade-induced neonatal brain injury: Reversal by the calcium channel agonist BayK 8644. Turner CP, Debenedetto D, Liu C.Neurosci Lett. 2009 Feb 6;450(3):292-5. doi: 10.1016/j.neulet.2008.12.002. Epub 2008 Dec 6. PMID: 19070650 Free PMC Article4:Gating of the HypoPP-1 mutations: II. Effects of a calcium-channel agonist BayK 8644. Kuzmenkin A, Hang C, Kuzmenkina E, Jurkat-Rott K.Pflugers Arch. 2007 Jul;454(4):605-14. Epub 2007 Mar 1. PMID: 17333247 5:Effects of the enantiomers of BayK 8644 on the charge movement of L-type Ca channels in guinea-pig ventricular myocytes. Artigas P, Ferreira G, Reyes N, Brum G, Pizarro G.J Membr Biol. 2003 Jun 1;193(3):215-27. PMID: 12962282 6:Transmission of information from cardiac dihydropyridine receptor to ryanodine receptor: evidence from BayK 8644 effects on resting Ca(2+) sparks. Katoh H, Schlotthauer K, Bers DM.Circ Res. 2000 Jul 21;87(2):106-11. PMID: 10903993 Free Article7:BayK 8644 increases resting calcium spark frequency in ferret ventricular myocytes. Satoh H, Hayashi H, Blatter LA, Bers DM.Heart Vessels. 1997;Suppl 12:58-61. PMID: 9476545 8:Anticonvulsant activity of calmodulin antagonist W-7 in convulsions induced by lindane and BayK-8644: effects in c-fos expression. Tusell JM, Barron S, Serratosa J.Neurotoxicology. 1994 Fall;15(3):751-6. PMID: 7531829 9:Inhibition of adenosine responses of rat hippocampal neurones by nifedipine and BAYK 8644. Bartrup JT, Stone TW.Brain Res. 1990 Aug 20;525(2):315-8. PMID: 1701332 10:Calcium agonist (BayK 8644) augments voltage-sensitive calcium currents but not synaptic transmission in cultured mouse spinal cord neurons. Yu C, Jia M, Litzinger M, Nelson PG.Exp Brain Res. 1988;71(3):467-74. PMID: 2458275