Bay 61-3606 Hydrochloride

• CAT Number: I004726
• CAS Number: 732983-37-8
• Molecular Formula: C₂₀H₁₈N₆O₃.HCl
• Molecular Weight: 426.86
• Purity: ≥95%
• Target: Spleen Tyrosine Kinase (Syk)
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 7.5 nM (Ki) [1]
• IUPAC Name: 2-[[7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide
• InChI: InChI=1S/C20H18N6O3.ClH/c1-28-15-6-5-12(10-16(15)29-2)14-11-17-22-8-9-26(17)20(24-14)25-19-13(18(21)27)4-3-7-23-19;/h3-11H,1-2H3,(H2,21,27)(H,23,24,25);1H
• InChIKey: HLYFDKZWVIBYKL-UHFFFAOYSA-N
• SMILES: COC1=C(C=C(C=C1)C2=CC3=NC=CN3C(=N2)NC4=C(C=CC=N4)C(=O)N)OC.Cl

Bay 61-3606 hydrochloride (Cat.No:I004726) is a potent and selective inhibitor of human neutrophil elastase (HNE) with potential anti-inflammatory and anti-tumor activity. It has been studied for its potential in treating chronic obstructive pulmonary disease (COPD) and other inflammatory diseases. It is available for research purposes and has not been approved for clinical use.

Reference

[1]. Yamamoto N, et al. The orally available spleen tyrosine kinase inhibitor 2-[7-(3,4-dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide dihydrochloride (BAY 61-3606) blocks antigen-induced airway inflammation in rodents. J Pharmacol Exp Ther. 2003 Sep;306(3):1174-81.

[2]. Lau KS, et al. BAY61-3606 affects the viability of colon cancer cells in a genotype-directed manner. PLoS One. 2012;7(7):e41343.