BAY-320

• CAT Number: I003984
• CAS Number: 1445830-50-1
• Molecular Formula: C26H26F2N6O2
• Molecular Weight: 492.53
• Purity: ≥95%
• Target: Bub1 kinase inhibitor
• Solubility: Soluble in DMSO
• Storage: 0 - 4 °C for short term or -20 °C for long term
• InChI: InChI=1S/C26H26F2N6O2/c1-4-36-18-11-20(27)19(21(28)12-18)14-34-24(16-5-6-16)15(2)23(33-34)26-30-13-22(35-3)25(32-26)31-17-7-9-29-10-8-17/h7-13,16H,4-6,14H2,1-3H3,(H,29,30,31,32)
• InChIKey: WAELFQHBZPHEMW-UHFFFAOYSA-N
• SMILES: COC1=CN=C(C2=NN(CC3=C(F)C=C(OCC)C=C3F)C(C4CC4)=C2C)N=C1NC5=CC=NC=C5

BAY-320(CAT: I003984) is a specific inhibitor of Bub1 kinase. Bub1 kinase is a key component of the mitotic checkpoint, which ensures accurate chromosome segregation during cell division. By inhibiting Bub1 kinase activity, BAY-320 disrupts the proper functioning of the mitotic checkpoint and impairs cell division. This inhibition can lead to abnormal chromosome segregation and cell death in rapidly dividing cells, such as cancer cells. BAY-320 shows potential as a targeted therapy for the treatment of various types of cancer, where dysregulated cell division is a hallmark feature.

Reference

1: Baron AP, von Schubert C, Cubizolles F, Siemeister G, Hitchcock M, Mengel A,
Schröder J, Fernández-Montalván A, von Nussbaum F, Mumberg D, Nigg EA. Probing
the catalytic functions of Bub1 kinase using the small molecule inhibitors
BAY-320 and BAY-524. Elife. 2016 Feb 17;5. pii: e12187. doi: 10.7554/eLife.12187.
PubMed PMID: 26885717; PubMed Central PMCID: PMC4769170.