(-)-BAY-1251152

• CAT Number: I019684
• CAS Number: 1610358-59-2
• Molecular Formula: C₁₉H₁₈F₂N₄O₂S
• Molecular Weight: 404.43
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: 5-fluoro-4-(4-fluoro-2-methoxyphenyl)-N-[4-[(methylsulfonimidoyl)methyl]pyridin-2-yl]pyridin-2-amine
• InChI: InChI=1S/C19H18F2N4O2S/c1-27-17-8-13(20)3-4-14(17)15-9-19(24-10-16(15)21)25-18-7-12(5-6-23-18)11-28(2,22)26/h3-10,22H,11H2,1-2H3,(H,23,24,25)
• InChIKey: YZCUMZWULWOUMD-UHFFFAOYSA-N
• SMILES: COC1=C(C=CC(=C1)F)C2=CC(=NC=C2F)NC3=NC=CC(=C3)CS(=N)(=O)C

(-)-BAY-1251152（Cat No.:I019684） is the enantiomer of BAY-1251152 with a negative rotation. BAY-1251152 itself is a potent and highly selective inhibitor of PTEF/CDK9, an enzyme involved in transcriptional regulation. By inhibiting PTEF/CDK9, BAY-1251152 can potentially disrupt cellular processes that rely on proper gene expression, particularly in the context of cancer.

Reference

[1]. Luecking, et al. Identification of potent and highly selective PTEFb inhibitor BAY 1251152 for the treatment of cancer: from p.o. to i.v. application via scaffold hops. AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 984. doi:10.1158/1538-7445.AM2017-984