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BAR-501

BAR-501

  • CAT Number: I003944
  • CAS Number: 1632118-69-4
  • Molecular Formula: C26H46O3
  • Molecular Weight: 406.4
  • Purity: ≥95%
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BAR-501 (Cat.No:I003944) is a selective GPBAR1 agonist devoid of any FXR agonistic activity. BAR501 effectively reduced hepatic perfusion pressure and counteracted the vasoconstriction activity of norepinephrine. BAR501 rescues from endothelial dysfunction in rodent model.

Catalog Number I003944
CAS Number 1632118-69-4
Molecular Formula

C26H46O3

Purity 95%
Target UDCA-like GPBAR1 agonist
Solubility Soluble in DMSO
Storage store at -20°C
IUPAC Name (3R,5S,6S,7S,8S,9S,10S,13R,14S,17R)-6-ethyl-17-[(2R)-5-hydroxypentan-2-yl]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol
InChI InChI=1S/C26H46O3/c1-5-18-22-15-17(28)10-12-26(22,4)21-11-13-25(3)19(16(2)7-6-14-27)8-9-20(25)23(21)24(18)29/h16-24,27-29H,5-15H2,1-4H3/t16-,17-,18+,19-,20+,21+,22+,23+,24+,25-,26-/m1/s1
InChIKey DQBAHTQWQZRMFH-CRPAWOMZSA-N
SMILES C[C@H](CCCO)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@@H](O)[C@@H](CC)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
Reference

</br>1: Renga B, Cipriani S, Carino A, Simonetti M, Zampella A, Fiorucci S. Reversal</br> of Endothelial Dysfunction by GPBAR1 Agonism in Portal Hypertension Involves a</br> AKT/FOXOA1 Dependent Regulation of H2S Generation and Endot

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