<p style=/line-height:25px/>BAMB-4(ITPKA-IN-C14) is a new membrane-permeable inhibitor against inositol-1,4,5-trisphosphate-3-kinase A((ITPKA) with IC50 of 37 uM in ADP-Glo Assay.<br>IC50 value: 37 uM<br>Target: ITPKA inhibitor<br>BAMB-4 exhibit the lowest inhibition frequency among the InsP3-Kinase inhibitors. only in one from 42 targets tested, BAMB-4 showed an inhibitory effect. Noteworthy, in kinase screens no targets of BAMB-4 were detected, indicating that the compound does not belong to the typical kinase inhibitors. Thus,<br>the relative high specicity and the high cellular uptake of BAMB-4 now for the rst provide the possibility to effectively inhibit InsP3kinase in vivo. e InsP3Kinase activity is essentially involved in ITPKA promoted metastasis of lung cancer cells, BAMB-4 is a promising therapeutic approach in lung cancer<br>therapy.</p>
| Catalog Number | I005337 |
| CAS Number | 891025-25-5 |
| Molecular Formula | C15H12N2O2 |
| Purity | 95% |
| Target | ITPKA inhibitor |
| Solubility | DMSO: ≥ 40 mg/mL |
| Storage | Store at -20C |
| IC50 | 37 uM |
| Reference | <p style=/line-height:25px/> |
