BAMB-4

  • CAT Number: I005337
  • CAS Number: 891025-25-5
  • Molecular Formula: C15H12N2O2
  • Molecular Weight: 252.27
  • Purity: ≥95%
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<p style=/line-height:25px/>BAMB-4(ITPKA-IN-C14) is a new membrane-permeable inhibitor against inositol-1,4,5-trisphosphate-3-kinase A((ITPKA) with IC50 of 37 uM in ADP-Glo Assay.<br>IC50 value: 37 uM<br>Target: ITPKA inhibitor<br>BAMB-4 exhibit the lowest inhibition frequency among the InsP3-Kinase inhibitors. only in one from 42 targets tested, BAMB-4 showed an inhibitory effect. Noteworthy, in kinase screens no targets of BAMB-4 were detected, indicating that the compound does not belong to the typical kinase inhibitors. Thus,<br>the relative high specicity and the high cellular uptake of BAMB-4 now for the rst provide the possibility to effectively inhibit InsP3kinase in vivo. e InsP3Kinase activity is essentially involved in ITPKA promoted metastasis of lung cancer cells, BAMB-4 is a promising therapeutic approach in lung cancer<br>therapy.</p>

Catalog Number I005337
CAS Number 891025-25-5
Molecular Formula

C15H12N2O2

Purity 95%
Target ITPKA inhibitor
Solubility DMSO: ≥ 40 mg/mL
Storage Store at -20C
IC50 37 uM
Reference

<p style=/line-height:25px/>
<br>[1]. Schroder D, et al. Identification of a new membrane-permeable inhibitor against inositol-1,4,5-trisphosphate-3-kinase A. Biochem Biophys Res Commun. 2013 Sep 20;439(2):228-34.
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