Bakuchiol

• CAT Number: I000184
• CAS Number: 10309-37-2
• Molecular Formula: C₁₈H₂₄O
• Molecular Weight: 256.38
• Purity: ≥95%
• Solubility: 10 mM in DMSO
• Storage: -20°C
• InChI: InChI=1S/C18H24O/c1-5-18(4,13-6-7-15(2)3)14-12-16-8-10-17(19)11-9-16/h5,7-12,14,19H,1,6,13H2,2-4H3/b14-12+/t18-/m1/s1
• InChIKey: LFYJSSARVMHQJB-QIXNEVBVSA-N
• SMILES: CC(=CCCC(C)(C=C)C=CC1=CC=C(C=C1)O)C

Bakuchiol (CAT: I000184) is a natural compound found in the seeds and leaves of the Psoralea corylifolia plant. It is classified as a meroterpene and has gained attention for its potential beneficial effects on the skin. Bakuchiol exhibits several pharmacological actions, including antioxidant, anti-inflammatory, and anti-aging properties. It has been studied as a natural alternative to retinol, a commonly used ingredient in skincare products. Bakuchiol has been shown to stimulate collagen production, improve skin elasticity, and reduce the appearance of wrinkles and fine lines. Additionally, it may help in managing various skin conditions, such as acne and hyperpigmentation. Bakuchiol offers a plant-based option for skincare formulations and is considered a gentler alternative to retinol with similar effects.

Reference

[1]. Chen Z, et al. Anti-tumor effects of bakuchiol, an analogue of resveratrol, on human lung adenocarcinoma A549 cell line. Eur J Pharmacol. 2010 Sep 25;643(2-3):170-9.

[2]. Xu Y, et al. In vitro evidence for bakuchiol/’s influence towards drug metabolism through inhibition of UDP-glucuronosyltransferase (UGT) 2B7. Afr Health Sci. 2014 Sep;14(3):564-9.

[3]. Li YG, et al. Fructus Psoraleae contains natural compounds with potent inhibitory effects towards human carboxylesterase 2. Fitoterapia. 2015 Jan 13;101C:99-106.

[4]. Lau KM, et al. Anti-dermatophytic activity of bakuchiol: in vitro mechanistic studies and in vivo tinea pedis-inhibiting activity in a guinea pig model. Phytomedicine. 2014 Jun 15;21(7):942-5.