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Baicalin

Baicalin

  • CAT Number: I002676
  • CAS Number: 21967-41-9
  • Molecular Formula: C21H18O11
  • Molecular Weight: 446.4
  • Purity: ≥95%
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Baicalin (CAT: I002676) is a natural flavonoid compound derived from Scutellaria baicalensis with multiple pharmacological activities. It exhibits anti-inflammatory effects by inhibiting pro-inflammatory cytokines and mediators. Baicalin also possesses antioxidant activity, and antimicrobial properties against bacteria, viruses, and fungi, and shows potential as an anticancer agent by inhibiting cancer cell growth and inducing apoptosis. Additionally, baicalin has hepatoprotective and neuroprotective effects. Its therapeutic applications include the treatment of inflammatory diseases, oxidative stress-related conditions, microbial infections, and certain types of cancer. The molecular targets of baicalin involved in its pharmacological effects are primarily related to inflammation, oxidative stress, and cancer pathways.

Catalog Number I002676
CAS Number 21967-41-9
Molecular Formula

C21H18O11

Purity 95%
Solubility DMSO: 32 mg/mL
Storage 3 years -20C powder
InChI InChI=1S/C21H18O11/c22-9-6-10(8-4-2-1-3-5-8)30-11-7-12(14(23)15(24)13(9)11)31-21-18(27)16(25)17(26)19(32-21)20(28)29/h1-7,16-19,21,23-27H,(H,28,29)/t16-,17-,18+,19-,21+/m0/s1
InChIKey IKIIZLYTISPENI-ZFORQUDYSA-N
SMILES OC1=C(O)C(C(C=C(C2=CC=CC=C2)O3)=O)=C3C=C1O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O4
Reference

</br>1:[Effect of baicalin on ATPase and LDH and its regulatory effect on the AC/cAMP/PKA signaling pathway in rats with attention deficit hyperactivity disorder]. Zhou RY, Wang JJ, You Y, Sun JC, Song YC, Yuan HX, Han XM.Zhongguo Dang Dai Er Ke Za Zhi. 2017 May;19(5):576-582. Chinese. PMID: 28506353 Free Article</br>2:A voltammetry sensor platform for baicalein and baicalin simultaneous detection in vivo based on Ta<sub>2</sub>O<sub>5</sub>-Nb<sub>2</sub>O<sub>5</sub>@CTS composite. Xie Z, Lu W, Yang L, Li G, Ye B.Talanta. 2017 Aug 1;170:358-368. doi: 10.1016/j.talanta.2017.04.022. Epub 2017 Apr 14. PMID: 28501181 </br>3:Baicalin Alleviates Nitroglycerin-induced Migraine in Rats via the Trigeminovascular System. Sun YY, Zhang WJ, Dong CL, Zhang XF, Ji J, Wang X, Wang L, Hu WL, Du WJ, Cui CL, Zhang CF, Li F, Wang CZ, Yuan CS.Phytother Res. 2017 May 10. doi: 10.1002/ptr.5811. [Epub ahead of print] PMID: 28488307 </br>4:Poly-dimensional network comparative analysis reveals the pure pharmacological mechanism of baicalin in the targeted network of mouse cerebral ischemia. Liu Q, Liu J, Wang P, Zhang Y, Li B, Yu Y, Dang H, Li H, Zhang X, Wang Z.Brain Res. 2017 Apr 29. pii: S0006-8993(17)30168-3. doi: 10.1016/j.brainres.2017.04.008. [Epub ahead of print] PMID: 28465229 </br>5:Baicalin ameliorates chronic unpredictable mild stress-induced depressive behavior: Involving the inhibition of NLRP3 inflammasome activation in rat prefrontal cortex. Liu X, Liu C.Int Immunopharmacol. 2017 Apr 28;48:30-34. doi: 10.1016/j.intimp.2017.04.019. [Epub ahead of print] PMID: 28460353 </br>6:Baicalin inhibits biofilm formation, attenuates the quorum sensing-controlled virulence and enhances Pseudomonas aeruginosa clearance in a mouse peritoneal implant infection model. Luo J, Dong B, Wang K, Cai S, Liu T, Cheng X, Lei D, Chen Y, Li Y, Kong J, Chen Y.PLoS One. 2017 Apr 28;12(4):e0176883. doi: 10.1371/journal.pone.0176883. eCollection 2017. PMID: 28453568 Free PMC Article</br>7:Role of generation on folic acid-modified poly(amidoamine) dendrimers for targeted delivery of baicalin to cancer cells. Lv T, Yu T, Fang Y, Zhang S, Jiang M, Zhang H, Zhang Y, Li Z, Chen H, Gao Y.Mater Sci Eng C Mater Biol Appl. 2017 Jun 1;75:182-190. doi: 10.1016/j.msec.2016.12.134. Epub 2017 Feb 13. PMID: 28415453 </br>8:Protective effects of baicalin on rabbit articular chondrocytes <i>in vitro</i>. Huang X, Wu H, Wang L, Zheng L, Zhao J.Exp Ther Med. 2017 Apr;13(4):1267-1274. doi: 10.3892/etm.2017.4116. Epub 2017 Feb 10. PMID: 28413465 Free PMC Article</br>9:Activation of PPARγ by baicalin attenuates pulmonary hypertension in an infant rat model by suppressing HMGB1/RAGE signaling. Chen Z, Wang Q.FEBS Open Bio. 2017 Mar 8;7(4):477-484. doi: 10.1002/2211-5463.12180. eCollection 2017 Apr. PMID: 28396833 Free PMC Article</br>10:Proteomic Analysis and Functional Studies of Baicalin on Proteins Associated with Skin Cancer. Li D, Lin B, Yusuf N, Burns EM, Yu X, Luo D, Min W.Am J Chin Med. 2017 Apr 6:1-16. doi: 10.1142/S0192415X17500355. [Epub ahead of print] PMID: 28385077

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