B02

• CAT Number: I003899
• CAS Number: 1290541-46-6
• Molecular Formula: C22H17N3O
• Molecular Weight: 339.4
• Purity: ≥95%
• Solubility: Soluble in DMSO
• Storage: 2-8°C
• IUPAC Name: 3-benzyl-2-[(E)-2-pyridin-3-ylethenyl]quinazolin-4-one
• InChI: InChI=1S/C22H17N3O/c26-22-19-10-4-5-11-20(19)24-21(13-12-17-9-6-14-23-15-17)25(22)16-18-7-2-1-3-8-18/h1-15H,16H2/b13-12+
• InChIKey: GEKDQXSPTHHANP-OUKQBFOZSA-N
• SMILES: C1=CC=C(C=C1)CN2C(=NC3=CC=CC=C3C2=O)C=CC4=CN=CC=C4

B02（Cat No.:I003899）, also known as RAD51-IN-02, is a compound that acts as an inhibitor of RAD51, a protein involved in DNA repair. B02 has been found to enhance the sensitivity of multiple myeloma (MM) cells to doxorubicin (DOX), a commonly used chemotherapy drug. By inhibiting RAD51, B02 disrupts DNA repair mechanisms, making MM cells more susceptible to the cytotoxic effects of DOX. This combination approach holds promise for improving the efficacy of DOX treatment in MM patients.

Reference

1: Alagpulinsa DA, Ayyadevara S, Shmookler Reis RJ. A Small-Molecule Inhibitor of RAD51 Reduces Homologous Recombination and Sensitizes Multiple Myeloma Cells to Doxorubicin. Front Oncol. 2014 Oct 30;4:289. doi: 10.3389/fonc.2014.00289. eCollection