Azvudine hydrochloride

• CAT Number: I015022
• CAS Number: 1333126-31-0
• Molecular Formula: C₉H₁₂ClFN₆O₄
• Molecular Weight: 322.68
• Purity: ≥95%
• IUPAC Name: 4-amino-1-[(2R,3S,4R,5R)-5-azido-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one;hydrochloride
• InChI: InChI=1S/C9H11FN6O4.ClH/c10-5-6(18)9(3-17,14-15-12)20-7(5)16-2-1-4(11)13-8(16)19;/h1-2,5-7,17-18H,3H2,(H2,11,13,19);1H/t5-,6-,7+,9+;/m0./s1
• InChIKey: MKMLHJHSIBILJH-DBSFTZRASA-N
• SMILES: C1=CN(C(=O)N=C1N)C2C(C(C(O2)(CO)N=[N+]=[N-])O)F.Cl

Azvudine hydrochloride（Cat No.:I015022） is a potent nucleoside reverse transcriptase inhibitor (NRTI) that exhibits antiviral activity against HIV, HBV, and HCV. It is highly effective against HIV-1 (with EC50s ranging from 0.03 to 6.92 nM) and HIV-2 (with EC50s ranging from 0.018 to 0.025 nM). Azvudine hydrochloride is also able to inhibit NRTI-resistant viral strains, making it a promising candidate for the treatment of viral infections.

Reference

[1]. Wang RR, et al. Azvudine, a novel nucleoside reverse transcriptase inhibitor showed good drug combination features and better inhibition on drug-resistant strains than lamivudine in vitro. PLoS One. 2014 Aug 21;9(8):e105617.