Azelastine

• CAT Number: I004190
• CAS Number: 58581-89-8
• Molecular Formula: C22H24ClN3O
• Molecular Weight: 381.9
• Purity: ≥95%
• Target: Histamine Receptor
• Solubility: 10mM in DMSO
• Storage: 3 years -20℃ powder
• IUPAC Name: 4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)phthalazin-1-one
• InChI: InChI=1S/C22H24ClN3O/c1-25-13-4-5-18(12-14-25)26-22(27)20-7-3-2-6-19(20)21(24-26)15-16-8-10-17(23)11-9-16/h2-3,6-11,18H,4-5,12-15H2,1H3
• InChIKey: MBUVEWMHONZEQD-UHFFFAOYSA-N
• SMILES: CN1CCCC(CC1)N2C(=O)C3=CC=CC=C3C(=N2)CC4=CC=C(C=C4)Cl

Azelastine (Cat.No:I004190) is an antihistamine and mast cell stabilizer used to treat allergic rhinitis and conjunctivitis. It works by blocking histamine receptors and reducing the release of inflammatory chemicals from mast cells. Azelastine can be administered as a nasal spray or eye drops and is generally well-tolerated with few side effects.

Reference

[1]. Kempuraj, D., et al., Azelastine is more potent than olopatadine n inhibiting interleukin-6 and tryptase release from human umbilical cord blood-derived cultured mast cells. Ann Allergy Asthma Immunol, 2002. 88(5): p. 501-6.

[2]. Canonica, G.W., et al., Topical azelastine in perennial allergic conjunctivitis. Curr Med Res Opin, 2003. 19(4): p. 321-9.

[3]. Lieberman, P., M.A. Kaliner, and W.J. Wheeler, Open-label evaluation of azelastine nasal spray in patients with seasonal allergic rhinitis and nonallergic vasomotor rhinitis. Curr Med Res Opin, 2005. 21(4): p. 611-8.