AZD9496

• CAT Number: I002137
• CAS Number: 1639042-08-2
• Molecular Formula: C25H25F3N2O2
• Molecular Weight: 442.5
• Purity: ≥95%
• Synonyms: (E)-3-(3,5-difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic acid
• Target: Estrogen/progestogen Receptor
• Solubility: DMSO: ≥ 104.5 mg/mL
• Storage: Store at -20°C
• IC50: 0.7 nM(Ki); 0.14 nM(ER downregulation cell IC50) [1]
• InChIKey: DFBDRVGWBHBJNR-BBNFHIFMSA-N

AZD9496 is a potent and orally bioavailable selective estrogen receptor downregulator(Ki=0.7 nM) and antagonist.IC50 value: 0.7 nM(Ki); 0.14 nM(ER downregulation cell IC50) [1]Target: ER downregulatorAZD9496 can induce ERα degradation in breast cancer cell lines at picomolar concentrations. AZD9496 is curently under clinical trials. AZD9496 may be useful for the treatment of ER+ breast cancer.

Reference

[1]. Discovery of the clinical candidate AZD9496: a potent and orally bioavailable selective estrogen receptor downregulator and antagonist.