AZD8330

• CAT Number: I005229
• CAS Number: 869357-68-6
• Molecular Formula: C16H17FIN3O4
• Molecular Weight: 461.23
• Purity: ≥95%
• Synonyms: 2-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxopyridine-3-carboxamide
• Target: MEK1/2
• Solubility: 10 mM in DMSO
• Storage: 3 years -20℃ powder
• IC50: 7 nM [1]
• InChI: InChI=1S/C16H17FIN3O4/c1-9-7-11(15(23)20-25-6-5-22)14(21(2)16(9)24)19-13-4-3-10(18)8-12(13)17/h3-4,7-8,19,22H,5-6H2,1-2H3,(H,20,23)
• InChIKey: RWEVIPRMPFNTLO-UHFFFAOYSA-N
• SMILES: CC1=CC(=C(N(C1=O)C)NC2=C(C=C(C=C2)I)F)C(=O)NOCCO

AZD8330 (Cat.No:I005229), also known as selumetinib, is a selective MEK1/2 inhibitor that is currently being studied as a potential anticancer agent. By inhibiting MEK1/2, which are key enzymes in the RAS-RAF-MEK-ERK pathway, AZD8330 blocks downstream signaling involved in cell proliferation and survival. Clinical trials are underway to evaluate its efficacy in various types of cancer.

Reference

1:[Effect of ERK1/2 inhibitor AZD8330 on human Burkitt/’s lymphoma cell line Raji cells and its mechanism]. Feng K, Wang C, Zhou H, Yang J, Dong L, Zhou K, Liu X, Song Y.Zhonghua Xue Ye Xue Za Zhi. 2015 Feb;36(2):148-52. doi: 10.3760/cma.j.issn.0253-2727.2015.02.014. Chinese. PMID: 25778893 2:[Effect of AZD8330 on proliferation and apoptosis of multiple myeloma cells]. Yao Y, Bian YP, Xia DD, Pan B, Niu MS, Zhao K, Zeng LY, Xu KL.Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2014 Oct;22(5):1311-5. doi: 10.7534/j.issn.1009-2137.2014.05.024. Chinese. PMID: 25338579 3:A phase I dose-finding, safety and tolerability study of AZD8330 in patients with advanced malignancies. Cohen RB, Aamdal S, Nyakas M, Cavallin M, Green D, Learoyd M, Smith I, Kurzrock R.Eur J Cancer. 2013 May;49(7):1521-9. doi: 10.1016/j.ejca.2013.01.013. Epub 2013 Feb 21. PMID: 23433846