AZD-7648

• CAT Number: I019387
• CAS Number: 2230820-11-6
• Molecular Formula: C₁₈H₂₀N₈O₂
• Molecular Weight: 380.4
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: 7-methyl-2-[(7-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(oxan-4-yl)purin-8-one
• InChI: InChI=1S/C18H20N8O2/c1-11-7-15-20-10-21-25(15)9-13(11)22-17-19-8-14-16(23-17)26(18(27)24(14)2)12-3-5-28-6-4-12/h7-10,12H,3-6H2,1-2H3,(H,19,22,23)
• InChIKey: XISVSTPEXYIKJL-UHFFFAOYSA-N
• SMILES: CC1=CC2=NC=NN2C=C1NC3=NC=C4C(=N3)N(C(=O)N4C)C5CCOCC5

AZD7648（Cat No.:I019387） is a highly potent inhibitor of DNA-dependent protein kinase (DNA-PK) with an IC50 value of 0.6 nM. It exhibits remarkable selectivity for DNA-PK, with more than 100 times higher affinity compared to other 396 kinases tested in a kinase library. DNA-PK is a crucial enzyme involved in DNA repair processes, and inhibiting its activity can potentially enhance the efficacy of DNA-damaging anticancer treatments. The high selectivity of AZD7648 makes it a promising candidate for targeted cancer therapies.

Reference

[1]. Maurice Raymond Verschoyle Finlay, et al. Amino-triazolopyridine compounds and their use in treating cancer. WO2018114999A1.