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AZD-5991

AZD-5991

  • CAT Number: I019688
  • CAS Number: 2143061-81-6
  • Molecular Formula: C₃₅H₃₄ClN₅O₃S₂
  • Molecular Weight: 672.26
  • Purity: ≥95%
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AZD-5991 (CAT: I019688) is a small-molecule inhibitor that targets the anti-apoptotic protein Mcl-1 (myeloid cell leukemia 1). Mcl-1 is a member of the Bcl-2 protein family and plays a critical role in promoting cancer cell survival by preventing apoptosis. AZD-5991 selectively binds to Mcl-1, displacing the pro-apoptotic proteins Bak and Bim, thereby promoting apoptosis in cancer cells. This inhibition of the Mcl-1 function has shown promising anti-cancer effects in preclinical studies, including both solid tumors and hematological malignancies. AZD-5991 is being investigated as a potential therapeutic option for cancer treatment, particularly in cases where elevated Mcl-1 levels contribute to treatment resistance. Clinical trials are underway to evaluate its safety and efficacy in cancer patients.

Catalog Number I019688
CAS Number 2143061-81-6
Molecular Formula

C₃₅H₃₄ClN₅O₃S₂

Purity 95%
Reference

[1]. Tron AE, et al. Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia. Nat Commun. 2018 Dec 17;9(1):5341.

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