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AZD 3988

AZD 3988

  • CAT Number: I011037
  • CAS Number: 892489-52-0
  • Molecular Formula: C23H22F2N4O4
  • Molecular Weight: 456.45
  • Purity: ≥95%
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AZD 3988 (Cat.No:I011037) is a potent and selective diacylglycerol acyltransferase (DGAT-1) inhibitor (IC<sub>50</sub> = 0.6 nM). Exhibits selectivity for DGAT-1 over DGAT-2, K<sub>v</sub>11.1 (hERG) and cytochrome P450 enzymes. Suppresses triacylglyceride (TAG) plasma excursion and adipose tissue TAG synthesis in rats. Reduces body weight of diet-induced obese rats. Cell permeable and orally bioavailable.

Catalog Number I011037
CAS Number 892489-52-0
Molecular Formula

C23H22F2N4O4

Purity 95%
Target DGAT
Solubility Soluble to 100 mM in DMSO and to 10 mM in 1eq. NaOH with gentle warming
Storage Store at 4℃
IUPAC Name 2-[4-[4-[[5-(3,4-difluoroanilino)-1,3,4-oxadiazole-2-carbonyl]amino]phenyl]cyclohexyl]acetic acid
InChI InChI=1S/C23H22F2N4O4/c24-18-10-9-17(12-19(18)25)27-23-29-28-22(33-23)21(32)26-16-7-5-15(6-8-16)14-3-1-13(2-4-14)11-20(30)31/h5-10,12-14H,1-4,11H2,(H,26,32)(H,27,29)(H,30,31)
InChIKey NGEBYTLALFOQKI-UHFFFAOYSA-N
SMILES C1CC(CCC1CC(=O)O)C2=CC=C(C=C2)NC(=O)C3=NN=C(O3)NC4=CC(=C(C=C4)F)F

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