Azatadine dimaleate

• CAT Number: I003451
• CAS Number: 3978-86-7
• Molecular Formula: C28H30N2O8
• Molecular Weight: 522.55
• Purity: ≥95%
• Target: Histamine Receptor
• Solubility: DMSO 105 mg/mL (200 mM); Water 105 mg/mL (200 mM)
• Storage: Store at -20°C
• IUPAC Name: (Z)-but-2-enedioic acid;2-(1-methylpiperidin-4-ylidene)-4-azatricyclo[9.4.0.03,8]pentadeca-1(15),3(8),4,6,11,13-hexaene
• InChI: InChI=1S/C20H22N2.2C4H4O4/c1-22-13-10-16(11-14-22)19-18-7-3-2-5-15(18)8-9-17-6-4-12-21-20(17)19;2*5-3(6)1-2-4(7)8/h2-7,12H,8-11,13-14H2,1H3;2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-
• InChIKey: SGHXFFAHXTZRQM-SPIKMXEPSA-N
• SMILES: CN1CC/C(CC1)=C2C3=CC=CC=C3CCC4=CC=CN=C42.O=C(O)/C=CC(O)=O.O=C(O)/C=CC(O)=O

Azatadine dimaleate(CAT: I003451) is a second-generation antihistamine drug that is used to treat various allergic conditions, such as seasonal allergies, allergic rhinitis, and urticaria. It works by selectively blocking the histamine H1 receptor, which is responsible for mediating allergic symptoms such as itching, sneezing, and runny nose. Azatadine dimaleate also has some anticholinergic and sedative properties, which may contribute to its therapeutic effects. It is commonly available in the form of tablets or syrups for oral administration. Azatadine dimaleate is generally well-tolerated but may cause some side effects such as drowsiness, dry mouth, and dizziness.

Reference

1: Hata K, Takagi M, Koga K, Shigematsu A. Stability of tritium-labelled azatadine dimaleate [6,11-dihydro-11 (1-methyl-4-piperidylidine)5H-benzo (5, 6) cyclohepta (1,2-b) pyridine dimaleate] of high specific activity. Radioisotopes. 1977 Jan;26(1):33-5. PubMed PMID: 577021.
2: Nove-Josserand G, Plauchu M. [Study of the action and tolerance of azatadine dimaleate in drug hypersensitivity]. Lyon Med. 1972 Mar 12;227(5):465-7. French. PubMed PMID: 5054522.